AdipoGen Life Sciences progranulin research tools

Progranulin (PGRN) is a cysteine-rich protein, composed of seven ~6 kDa granulin (GRN) proteins, that shows multifunctional biological activities including major roles in cancer, inflammation, metabolic disease and neurodegeneration — especially as a valuable biomarker for frontotemporal lobar degeneration (FTLD).

PGRN is an abundant, non-conventional, stress-induced, extracellular matrix-bound secreted growth factor-like molecule and cytoplasmic chaperone that functions in a cellular and disease-specific pattern. PGRN binds to several functionally different receptor families in a cell/tissue-specific and condition/disease-dependent manner.

In the brain, PGRN is primarily expressed in mature neurons and microglia. Absence of progranulin in microglia causes increased production and release of multiple cytokines, suggesting that PGRN regulates microglia activation. PGRN seems to affect microglial proliferation, recruitment, differentiation, activation and phagocytosis, suggesting that PGRN plays a central role in the regulation of neuroinflammatory responses.

AdipoGen Life Sciences has a comprehensive range of progranulin research products available including progranulin recombinant proteins, ELISA kits to measure progranulin and antibodies for detection of progranulin.