Beckman Coulter Life Sciences Valita Aggregation Pure assay

Beckman Coulter Life Sciences’ Valita Aggregation Pure assay is a plate-based, 96-well screening tool that offers rapid, high-throughput protein aggregation detection and quantification, providing robust aggregation data in as little as 15 min.

Traditional workflows in monoclonal antibody production require long wait times of up to 6 h to determine protein aggregation levels. The assay is designed to be one of the fastest and simplest aggregation detection tools on the market and is compatible with high-performance microplate readers with fluorescence polarisation functionality. It reduces manual steps and eliminates the need for additional reagents, enabling laboratory staff to get results fast and focus their efforts on critical research goals.

The assay enhances the process development workflow by enabling detection and quantification of antibody aggregation at any stage of time. In less than 15 min, aggregation can be quantified by simply adding purified samples to the plate, incubating at room temperature and measuring aggregation using a plate reader. Available as 96-well plates and validated with samples concentrated between 200 and 2000 mg/L, with a detection limit of 0.5% aggregation at 1000 mg/L, the assay enables rapid, high-throughput protein aggregation analysis.