Bio-Rad Laboratories scATAC-Seq single-cell open chromatin sequencing assay

Bio-Rad Laboratories has launched its scATAC-Seq assay, which facilitates genome-wide open chromatin sequencing at the single-cell level, to help researchers better understand gene expression regulation.

The product harnesses Bio-Rad’s ddSEQ Single-Cell Isolator to encapsulate thousands of cell nuclei into nanolitre-sized droplets to facilitate library preparation for ATAC sequencing. Unlike other products, it does not require separate assays to collect this information and does not require millions of cells as starting material due to its high capture efficiency.

The product offers users a good level of sensitivity by providing the highest number of unique sequencing fragments that map to the nuclear genome, ATAC peaks and transcription start sites. With a cell capture efficiency of up to 95%, it provides a powerful tool to help researchers understand the factors that shape cell differentiation and cell fate.