HumanZyme HumaXpress human cell expression system

Stem cell, regenerative medicine and cellular therapy labs conducting research, development and clinical trials benefit from the use of authentic human proteins with the best possible activity and stability for human cell-based studies. For this reason, HumanZyme has developed the HumaXpress human cell expression system, which produces authentic recombinant HumanKine proteins with correct post-translational modifications, subunit assembly, folding, secretion and stability. The company’s HEK293 expression system produces mature, authentically human proteins with native biological function.

Correctly glycosylated recombinant human cytokines from a human cell line offer certain advantages over proteins produced in E. coli or CHO cells, including good stability and activity in cell culture. The HumaXpress system produces proteins with native human folding and glycosylation that often demonstrate high stability and specific activity over proteins produced in E. coli, according to the company.

In addition, the system correctly assembles protein subunits, eg, human IL-23, a glycosylated heterodimer formed by the two subunits p19 and p40. Mature, native IL-23 from HumanZyme contains both authentic human glycosylation as well as the natural disulfide bond linking the two subunits.