Merck GenElute-E Single Spin purification kits

Merck is helping to improve productivity in the lab through a flexible and streamlined nucleic acid purification process — GenElute-E Single Spin purification kits.

Nucleic acid purification, the purification of genomic DNA and RNA, is an essential step in the pursuit of scientific answers to many health-related questions. It is used in virus detection and surveillance, research and therapeutic development and wastewater testing, and performed before downstream applications such as next-generation sequencing.

The kits enable nucleic acid purification without the need for multiple binding and wash steps by separating molecules in the sample by size using negative chromatography technology. Hands-on time is reduced from 45 min on average to only 3 min, compared with silica-based kits.

The kit’s application-specific SmartLyse enzymes create lysis times of only 10–40 min, eliminating overnight processing requirements, which are traditionally required for challenging samples. The kits reduce lysis and nucleic acid purification steps to under an hour.

Merck’s GenElute-E Single Spin Technology workflow is designed to reduce plastic waste on average by 55%, compared with traditional methods, thus providing a more sustainable alternative and reducing lab waste disposal costs.