Merck Millipore Magna Nuclear RNA-binding Protein Immunoprecipitation (RIP) Kits

Merck Millipore has introduced the Magna Nuclear RNA-binding Protein Immunoprecipitation (RIP) kits. The kits are designed to allow the discovery and analysis of both coding and non-coding chromatin-associated RNAs.

Two versions of the kit are available, enabling users to analyse RNA both strongly and weakly associated with chromatin; one version uses cross-linked chromatin while the other uses native chromatin. Native RIP allows recovery of high-affinity, more direct interactions while the cross-linked method is designed to capture higher molecular weight complexes and more readily trap weaker interacting RNAs.

Compared with other kits available to researchers, the product is said to deliver lower background signals and high signal-to-noise ratios, and has been demonstrated to work in RNA-seq to enable NGS-based discovery and profiling. The kits offer flexible and scalable input requirements; RNA can be recovered from as few as 5000 cells (cross-linked) or 100,000 cells (native).