Merck Mobius single-use bioreactors

Single-use, disposable equipment and systems have increased in popularity in the biopharmaceutical industry, offering advantages over conventional stainless steel systems including improved batch success rates, less cross-contamination risk, decreased water and wastewater requirements, and shortened project duration. At the same time, biopharmaceutical manufacturers are moving towards end-to-end solutions — from process development and scale-up through to manufacturing for preclinical, clinical and commercial supply — as they seek to increase quality and efficiency.

Merck’s portfolio of 3 to 2000 L Mobius single-use bioreactors delivers flexibility and continuity for scale-up, reducing the need for retraining operators. The bioreactors thus enable laboratories to streamline their processes and expand their capacity.

The bioreactors provide flexibility by configuring software, hardware and single-use assemblies for use in suspension and adherent cell culture applications. They can function as standalone systems or be integrated as part of a facility’s automation platform.

All systems have doors and viewing windows, providing easy access to expendables and visibility on the status of the working volume and mixing steps. CCP software meanwhile provides the user with one familiar interface that simplifies software management and reduces the learning curves for inexperienced operators.