RF360 high-resolution system for ADME assays

Biocius Life Sciences and Agilent Technologies have released the RF360 high-resolution system for high-throughput screening of in-vitro ADME assays.

Combining the accurate mass capabilities of Agilent’s time-of-flight mass spectrometers and the sample processing speed of RapidFire technology, the instrument eliminates the method development bottleneck in drug discovery.

RapidFire technology combined with TOF mass spectrometers enables a range of ADME assays, including drug-drug interaction, metabolic stability, Caco, PAMPA and others.

When performing such assays with the system, a prior knowledge of the test compound is not required, as data is acquired in full scan TOF-MS mode.

Post acquisition, the relevant data is extracted using RapidFire software, eliminating the time-consuming and labour-intensive steps of LC/MS method development and batch analysis.