Logos Biosystems X-CLARITY system for streamlined tissue clearing

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Visualising intact biological structures in three dimensions remains a major challenge for researchers. Conventional histology techniques require thin tissue slicing, which can distort spatial relationships and make it difficult to interpret complex cellular networks. Thick or whole-tissue imaging, on the other hand, is hindered by light scattering caused by lipids, leading to opaque samples and poor imaging depth. There is a growing need for standardised clearing methods to clear tissues efficiently without damaging structure or losing fluorescent signals.

The X-CLARITY system from Logos Biosystems addresses these challenges by automating and standardising the tissue clearing process. Using proprietary electrophoretic tissue clearing (ETC) technology, the system rapidly and uniformly removes lipids from fixed tissues, rendering them optically transparent while maintaining molecular and structural integrity.

The X-CLARITY tissue clearing system, together with dedicated hydrogel and mounting solutions, provides an all-in-one, easy-to-use workflow from start to finish. The process can clear a mouse brain in just a few hours, eliminating manual variability and improving consistency across samples.

Once cleared, tissues can be imaged using confocal, two-photon or light sheet microscopy to reveal intricate 3D architecture — from neuronal pathways and vascular networks to tumour microenvironments. By simplifying and accelerating tissue clearing, the system empowers researchers in neuroscience, developmental biology and pathology to gain deeper insight into biological systems.

ATA Scientific provides demonstrations and expert support to help laboratories adopt this transformative workflow. To see the benefits for yourself, contact the company or visit https://www.atascientific.com.au/products/logos-biosystems-x-clarity/.