Inflammation slows malaria parasite growth in the body

Research led by The Peter Doherty Institute for Infection and Immunity and the Kirby Institute has found that inflammation in the body can slow down the development of malaria parasites in the bloodstream — a discovery that may constitute a potential new strategy for preventing or limiting severe disease.

Malaria is caused by Plasmodium parasites, which invade and multiply within red blood cells. Previous research has shown that the parasites can rapidly sense and respond to conditions within the host by intimately syncing with their internal body clocks. While it is known that the body’s nutrient levels and daily circadian rhythms affect the parasites’ development, little is known about the impact of host inflammation on the parasites.

The new animal-model study, published in the journal mBio, reveals that when the body’s immune system responds to inflammation it alters the chemical make-up of the plasma, which directly hinders the maturation of the Plasmodium parasites as they circulate in the bloodstream. The University of Melbourne’s Associate Professor Ashraful Haque, a Laboratory Head at the Doherty Institute and co-senior author on the paper, said this work highlights the captivating dynamic of the host–parasite relationship.

“First, we discovered that inflammation in the body prevented the early stage of the parasites from maturing,” Haque said. “We also noticed that inflammation triggered significant changes in the composition of the plasma — we were actually quite surprised by the magnitude of these changes.

“As we dug deeper, we found substances in the altered plasma that, we believe, are what may inhibit parasite growth in the body. This work reveals a new mechanism that slows down the malaria parasite’s development in the bloodstream. Our research was done using animal models, so it would be really interesting to study if such inhibitory mechanisms occur in humans too.”

Dr David Khoury, Lead of the Malaria Analytics Group at the Kirby Institute and co-senior author of the paper, said the scientists found a remarkable response by the parasites to the changes in their environment.

“Parasites residing in red blood cells rapidly sense and respond to their new environment, showing fascinating adaptability,” Khoury said. “Using cutting-edge genome sequencing technology, we observed that even after just four hours in this changed plasma, the parasites adjusted their genetic and protein activity, resulting in slower maturation within red blood cells. It’s almost like the parasites actively sense an inhospitable host environment, and as a result trigger a coping mechanism.

“We believe this is the first study to show that inflammation can change how individual parasites behave genetically in the body.”

Professor Miles Davenport, Program Head of the Infection Analytics Program at the Kirby Institute and co-senior author of the paper, said this work on the interaction between systemic host inflammation and malaria parasite maturation offers several potential benefits.

“This study, while based on animal models, broadens our understanding of malaria,” Davenport said. “It provides a foundation for further investigations into the specific mechanisms involved in the modulation of parasite maturation by inflammation, and opens avenues for future studies to explore the identified inhibitory factors, genetic changes and their implications for malaria development.

“Ultimately, our work aims to, one day, inform the development of potential new strategies to control, prevent and reduce the burden of malaria.”

Image credit: iStock.com/Dr_Microbe