SCIEX Intabio ZT charge variant analysis system

SCIEX has launched the Intabio ZT system — a fully integrated, microfluidic chip-based platform combining imaged capillary isoelectric focusing (icIEF) separation and UV detection. When coupled with mass spectrometry (MS) identification on the ZenoTOF 7600 system, it can eliminate the guesswork from early drug development stages and accelerate drug candidate selection. This icIEF-UV/MS workflow enables separation, quantitation and identification of biopharmaceutical charge variants and their proteoforms.

The Intabio ZT system can acquire data on charge isoforms for biopharmaceuticals in minutes instead of weeks. This capability targets a key bottleneck in biopharmaceutical characterisation, where lack of connectivity between icIEF and MS assays can hamper the identification of unknown peaks early in the development process. The system also harnesses the sophisticated data processing capability within Biologics Explorer software to unlock more information.

By providing mass information on charge variants, the product has the power to change protein therapeutic development by providing the comprehensive data needed to make quick and confident decisions on the developability of potential therapies.