S-Matrix Corporation Fusion Method Development software

Wednesday, 03 February, 2010 | Supplied by: Waters Australia Pty Ltd



Waters has become the exclusive distributor of Fusion Method Development software, developed by S-Matrix Corporation. The software works seamlessly with Waters Empower 2 chromatography data software (CDS) and Acquity UltraPerformance LC (UPLC) to automate liquid chromatographic method development according to quality-by-design (QbD) guidelines. Fusion not only greatly accelerates method development, it enables development of more robust methods which transfer successfully and withstand the test of repeated use.

Using a QbD-based methodology for LC method development allows scientists to develop the best possible method much faster and with much greater confidence. Fusion works with Empower 2 and Acquity UPLC to increase laboratory efficiency by designing statistically valid experiments and automatically reconstructing them in Empower 2 as fully ready-to-run sequences.

Fusion uses the resulting data to generate parameter-effects models which establish the final design and operating spaces for optimised LC methods. This automated process ensures that scientists develop the right method the first time and translate chromatographic data into information, knowledge and answers.

Fusion Method Development also addresses regulatory recommendations to incorporate robustness into LC method development. Utilising an approach built on sound statistical process control techniques, the software computes and models the impact of key chromatographic parameters on method robustness. This enables identification of methods optimised for both mean performance and robustness without the need for any additional experiments. Establishing the final design space for a method in this manner creates the basis for regulatory flexibility and continuous improvement.

Use of Fusion Method Development software crosses virtually all laboratories served by LC, including pharmaceutical, food and beverage, fine chemicals, and environmental laboratories.

Online: www.waters.com
Phone: 02 9933 1777
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