PUMA, also known as the p53 upregulated modulator of apoptosis, is a protein that belongs to the BCL-2 family of proteins. It plays a critical role in the regulation of cell death and cancer development. PUMA is a pro-apoptotic protein that is activated in response to DNA damage and other cellular stress signals. It is known to bind to and inhibit anti-apoptotic Bcl-2 proteins (Bax and Bak), thereby promoting the activation of the intrinsic apoptotic pathway. PUMA has been found to be upregulated in a variety of cancers due to oncogenic stress, oxidative stress and DNA damage (to name a few), making it an attractive target for cancer therapy.
The study of PUMA has gained significant attention in recent years, particularly in the field of cancer research and in mitophagy and autophagy research. The ability to detect and measure PUMA levels in cells and tissues is crucial for understanding its role in cell death and its relationship to p53. ProSci’s PUMA antibody preparations have been validated for western blot, ELISA, immunocytochemistry and immunofluorescence. They have been used in various studies to detect PUMA expression in cell lines and in primary tissues, including cancer cell lines and normal tissues.
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