Corn Trypsin Inhibitor (CTI) from Haematologic Technologies is not only an inhibitor of trypsin but is also a specific human factor XIIa inhibitor when tested in blood-clotting experiments.
The inhibitor forms a one-to-one complex with either trypsin or factor XIIa and, when added to plasma, prolongs the activated partial thromboplastin time without affecting the PT assay.
The specificity for factor XIIa makes the inhibitor suitable for the segregation and study of coagulation reactions.
CTI can be used to suppress the contact pathway of coagulation when attempting to perform TF-dependent assays in whole blood or plasma samples. The addition of CTI at the point of sample collection can prevent activation of the contact pathway during subsequent sample processing steps, thus reducing in-vitro artifact.
A common application of CTI is associated with thrombin generation assays when attempting to work at low TF concentrations.
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