Plexpress announces collaboration with Admescope

Plexpress, developer of the innovative TRAC platform for high-throughput gene expression analysis, has announced a collaboration with the contract research organisation Admescope which will now include TRAC as part of its services for investigating in vitro drug interactions and preclinical ADME-Tox responses.

Admescope customers can now take advantage of the benefits offered by Plexpress’ TRAC (Transcript Analysis with the aid of Affinity Capture) technology. These are said to include higher sample throughput, increased assay speed and reduced technical variation when compared to similar gene expression analyses undertaken using qPCR or microarrays. In the first instance, Admescope will offer Plexpress’ multiplex assays targeting the Cytochrome P450 (CYP) family, which can be used as an insightful indicator of potential drug toxicity and efficacy.

The new service is particularly well suited to meeting recent draft recommendations from the FDA, which suggest that CYP mRNA analysis might be more informative for drug metabolism studies than measuring CYP activity.