Biolin Scientific Q-Sense instruments for studying biosurface interactions

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Q-Sense instruments enable the study of molecular binding and interactions with surfaces using the principle of quartz crystal microbalance with dissipation (QCM-D). The systems offer real-time, label-free measurement of the mass of thin films with nanogram sensitivity and simultaneously provide novel insights about their structure.

Q-Sense Dfind is easy-to-use software for analysing QCM-D data which complements the latest product family and includes the Q-Sense Pro, Q-Sense Analyzer, Q-Sense Explorer and Q-Sense Initiator. Q-Sense Initiator is for those interested in real-time monitoring of surface interactions but only need the basic functions of a QCM-D instrument. Graphene oxide (GO) is now included in the long list of coating materials in the Q-Sense product range.

Applications include adsorption and desorption kinetics, film thickness and level of hydration, protein aggregation and conformational changes upon binding of a ligand or cross-linker. Interactions can be studied on substrates such as gold, metals, polymers and functionalised coatings. The measurement chamber is available in single- and four-channel versions and can be combined with techniques such as electrochemistry, ellipsometry and microscopy.