Malvern Zetasizer Pro and Ultra bioparticle characterisation tool

Monday, 01 July, 2019 | Supplied by: ATA Scientific Pty Ltd


For over two decades, the Malvern Zetasizer range has helped improve product quality and stability of a wide range of particles and biomolecules and protein-based drug formulations. Using dynamic light scattering (DLS), the Zetasizer offers an easy-to use, flexible sizing method which is rapid and repeatable. It requires only small volumes of sample for analysis, and is non-destructive. Patented non-invasive back-scatter (NIBS) technology combines backscatter detection with variable measurement positioning to increase the range of sample concentration and size that can be measured, compared to conventional DLS.

Built on the Zetasizer Nano range, the Zetasizer Pro and Ultra systems from Malvern Panalytical are the latest iteration of the Zetasizer series. Several powerful capabilities have now been integrated into the range.

By using statistical analysis and optimised data collection, adaptive correlation helps to improve the repeatability of DLS particle size measurements and the ability to measure primary particle sizes separately to rare amounts of aggregated material. These improvements mean that fast, high-precision measurements may be achieved with less need for filtering of samples and dispersants.

A key differentiator of the Zetasizer Ultra is its patented multi-angle dynamic light scattering (MADLS) technology, which automates multiple-angle size measurements, providing higher resolution and more complete particle size distributions. MADLS also enables calibration-free particle concentration analysis, resolving the individual concentrations of different size populations. The disposable capillary sizing cell provides non-destructive, low volume (3 μL) analysis, extending the upper range to 10 μm and delivering high-quality data.

The Zetasizer Pro and Ultra systems are controlled by ZS Xplorer deep learning software, introducing sample-centric workflows, which make method design and data analysis more straightforward for both new and experienced users. This intelligent network provides feedback on results and offers clear advice on how data may be improved if required.

For more information:

Phone: 02 9541 3500
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