Purification portfolio

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Phenomenex has introduced its product portfolio for purifying synthetic oligonucleotides, Clarity BioSolutions.

This is a portfolio of products, including desalting tubes, HPLC columns and cartridges, for the purification of synthetic oligonucleotides. A variety of purification options is provided to support different strategies based on purity and yield requirements, throughput goals, diverse oligo chemistries and lab resources.

Clarity Triophilic purification cartridges have a specifically engineered sorbent that purifies a desired full-length oligonucleotide sequence from failure sequences and other impurities.

The cartridges deliver 90-95% purity and yields using a universal, simple protocol for all oligonucleotide chemistries including DNA, RNA, siRNA, phosphorothioates, dye-labelled, etc.

The multiplex format results in the purification of 96 samples in 30 mins and is amenable to automation.

Clarity Oligo-RP is a range of reversed phase HPLC columns designed for purifying synthetic DNA and RNA. The column media is based on Twin technology and gives improved selectivity and efficiency.

This results in 95% typical purity, loading capacity from 50 nmole to greater than 5 µmole and the ability to separate n-1mer from target sequence.