Enzo PROTEOSTAT Aggresome Kit

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Aggresomes are inclusion bodies that form when the ubiquitin-proteasome machinery is overwhelmed with aggregation-prone proteins. Certain inclusion bodies associated with human disease are thought to arise from an aggresomal response, including Alzheimer’s disease as it relates to intracellular and extracellular aggregates, Lewy bodies associated with neurons in Parkinson’s disease and more.

Enzo’s PROTEOSTAT Aggresome Kit, a cell-based assay to detect aggresome formation, can be used to achieve physiologically relevant results. The product provides a sensitive cell-based assay of drug responsiveness to identify inhibitors relevant to neurodegenerative disease in an authentic cellular context. It easily quantifies aggresome and related inclusion bodies by flow cytometry.

The simple assay does not require non-physiological protein mutations or genetically engineered cell lines. It has been validated under a wide range of conditions and with small molecule modulators, demonstrating suitability for screening compounds of potential therapeutic value. The kit is useful for the study of neurodegenerative diseases, liver disease, toxicology studies and more.