Inverted research microscope

To satisfy the demands of today’s high-end research, Nikon has developed the new Ti series of microscopes. Combined with NIS-Elements imaging software, the Ti supports diverse imaging acquisition and analysis methods such as multi-dimensional time-lapse imaging to acquire temporal, spatial and spectral information of fast, dynamic live cell processes. Intelligently designed automation and further expansion of Nikon’s powerful modular approach make the Ti ideal for applications such as confocal, FRET, High Contact Analysis (HCS), and photobleaching/photoactivation to study interaction of fluorescence protein molecules in living cell tissues. Advanced functions of Ti-E dramatically expand research imaging possibilities: high-speed motorised components allow fast, coordinated and seamless imaging acquisition; multimode scanning of well plate at an unprecedented speed; Built-in Perfect Focus System (PFS) for automatic focus correction; newly developed “full intensity” optical components enable phase contrast with high NA non-phase-contrast objectives; image acquisition and analysis with multiple side ports and back port cameras; motorised laser TIRF (total internal reflection fluorescence) observation; the photo activation unit allows cell marking and dynamic analysis using photoactivatable and photoswitchable proteins such as PA-GFP and Kaede; seamless integration with confocal microscope systems for high-performance spectral confocal imaging. Coherent Scientific www.coherent.com.au