6 tips for optimising antibiotic use


Thursday, 02 May, 2019


6 tips for optimising antibiotic use

Seeking to combat the threat of antibiotic resistance, researchers from the University of Leicester have provided a set of recommendations about how to address the overuse of antibiotics in health care.

The research, led by Dr Carolyn Tarrant and published in the journal Clinical Microbiology and Infection, highlights how the global problem of antibiotic resistance can be overlooked in favour of more immediate concerns, including the consequences of missing a serious infection. It includes six simple tips for a coordinated approach to optimising antibiotic use:

  • Access to antibiotics should be carefully regulated.
  • The immediacy of the problem of resistance should be emphasised.
  • Rules for antibiotic prescribing should be made collectively, with involvement of clinicians and patients.
  • Doctors’ prescribing behaviour should be monitored and fed back to them.
  • Reputational incentives and sanctions should be introduced.
  • Perverse incentives that drive overuse should be addressed.
     

“Rather than expecting individual doctors to bear the responsibility for reducing their prescribing to protect antibiotics for the future, our research argues that we should use more collective approaches,” Dr Tarrant said. “This means establishing consensus rules for antibiotic use, sharing data on prescribing and using public reputation as a way of encouraging good prescribing practice.

“Current approaches to reducing antibiotic overuse tend to focus on the behaviour of individual prescribers, but our research identifies the need for coordinated action across whole communities of prescribers.”

Dr Eva Krockow, a co-author on the study, added, “Often it’s hard to tell whether patients have bacterial infections and need antibiotic treatment. Under circumstances of uncertainty, doctors worry about missing an infection and the patient deteriorating; to be safe, they err on the side of overprescribing.

“This means that doctors sometimes prescribe antibiotics when they aren’t helpful — in cases of viral infections such as colds — or when they aren’t necessary — in cases where a bacterial infection may clear on its own. This seems rational on an individual level, but leads to an overall outcome of reduced antibiotic effectiveness.”

In a linked publication, led by Professor Andrew Colman and published in the journal PLOS ONE, the researchers provide the grounding for these recommendations. They prove that the choices doctors face when deciding to prescribe an antibiotic take the form of a tragedy of the commons dilemma — where individual decisions to overuse antibiotics may provide the best short-term outcome for individual doctors and their patients, but the overall outcome of loss of antibiotic effectiveness through overuse is collectively worse for all.

“If doctors behave perfectly rationally, always acting in the interests of their patients, the inevitable result will be bad for them and their patients,” Professor Colman said. “Unless appropriate steps are taken, antibiotic prescribing will be increased until they are no longer effective.

“Solutions to this type of problem involve collective commitment to common goals and cooperation between those using the shared resource.”

Image credit: ©stock.adobe.com/au/Sasa Komlen

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