Abnormal brain protein targeted in Parkinson's study


Tuesday, 08 July, 2025

Abnormal brain protein targeted in Parkinson's study

Researchers at The University of Sydney have identified a new brain protein involved in the development of Parkinson’s disease and a way to modify it, paving the way for future treatments for the disease.

Parkinson’s disease is the second most common neurological condition after dementia, with over 150,000 people in Australia living with the condition. It is a degenerative neurological disorder in which dopamine-producing cells in the brain die, leading to symptoms including tremors, muscle stiffness, slow movement and impaired balance.

The Sydney research team, led by Professor Kay Double from the Brain and Mind Centre, has spent more than a decade studying the biological mechanisms underpinning Parkinson’s, with the aim of finding new treatments to slow or stop its progression. In 2017 the team led a study identifying the presence of an abnormal form of a protein — called SOD1 — in the brains of patients diagnosed with Parkinson’s disease, which they published in the journal Acta Neuropathologica.

Normally, the SOD1 protein provides protective benefits to the brain but, in Parkinson’s patients, it becomes faulty, causing the protein to clump and damage brain cells. The research team has now found that targeting the faulty SOD1 protein with a drug treatment improved the motor function in mice bred to have Parkinson-like symptoms, with their results published in Acta Neuropathologica Communications.

The study involved two groups of mice bred to have Parkinson-like symptoms. One group of mice was treated with a special copper supplement for three months, while the other received a placebo.

Throughout the study, the mice receiving the placebo saw a decline in their motor symptoms. The mice receiving the special copper supplement, however, did not develop movement problems.

“All the mice we treated saw a dramatic improvement in their motor skills, which is a really promising sign it could be effective in treating people who have Parkinson’s disease too,” Double said.

“We hoped that by treating this malfunctioning protein, we might be able to improve the Parkinson-like symptoms in the mice we were treating — but even we were astonished by the success of the intervention.

“The results were beyond our expectations and suggest, once further studies are carried out, this treatment approach could slow the progression of Parkinson’s disease in humans.”

The researchers’ next step is to identify the best approach to targeting the faulty SOD1 protein in a clinical trial, which could be the start of a new therapy to slow the development of Parkinson’s disease.

“As our understanding of Parkinson’s disease grows, we are finding that there are many factors contributing to its development and progression in humans — and faulty forms of the SOD1 protein is likely one of them,” Double said.

“Just as researchers found with HIV, Parkinson’s disease is a complex condition that likely requires multiple interventions. A single treatment may have a small effect when used alone but, when combined with other interventions, contributes to a significant overall improvement in health.”

Image credit: iStock.com/wildpixel

Related News

Epilepsy disease model treated in a laboratory dish

A research team has used an epilepsy-like disease model in a laboratory dish to demonstrate that...

Newborns have elevated levels of an Alzheimer's biomarker

What do the brains of newborns and patients with Alzheimer's disease have in common? Both...

Cannabis use may double risk of cardiovascular disease death

Cannabis users have a 29% higher risk of acute coronary syndrome, a 20% higher risk of stroke,...


  • All content Copyright © 2025 Westwick-Farrow Pty Ltd