Blood flow 'master controller' discovered in the brain

An international team of scientists, including Australians, has discovered a group of brain cells that function as a ‘master controller’ for the cardiovascular system by orchestrating the control of blood flow to different parts of the body. Published in The Journal of Physiology, their discovery may pinpoint where cardiovascular issues such as high blood pressure and heart failure are controlled in the brain.

Using genetically modified viruses in an animal model, the researchers were able to make brain cells that govern blood flow glow under the microscope — allowing them to trace, for the first time, the cells’ connections to multiple parts of the cardiovascular system. They identified one critical group of cells in the most evolutionarily ancient part of the brain, the medulla oblongata, that send connections to multiple cardiovascular targets, suggesting a pre-eminent role for these cells.

In a follow-up study the team rendered those same brain cells sensitive to laser light (a technique called optogenetics), allowing them to control their activity with the flick of a switch. Brain cells were found to simultaneously exert influence on multiple regions of the body, including the heart and the blood vessels of both the forelimbs and hindlimbs, suggesting that the function of these cells is to coordinate activity across the cardiovascular system as a whole.

The team included researchers from Sydney’s Macquarie University, led by Associate Professor Simon McMullan. He said the study reveals how the brain directs blood flow to different parts of the body, a finding which has puzzled neuroscientists for many years.

“We found that brain cells broadcast their message to many different targets to coordinate global control of blood flow,” said Assoc Prof McMullan.

“The brain’s control over your heart and blood vessels is essential for your survival. Even doing something as simple as going from lying down to a sitting up position can cause huge shifts in blood flow that, if left unchecked, could threaten your ability to stay conscious and therefore alive.”

The study also featured researchers from Melbourne’s Florey Institute of Neuroscience and Mental Health, led by Professor Robin McAllen. He said, “The body needs to orchestrate competing demands for blood from different tissues at different times. We have discovered master controllers of the cardiovascular system that regulate the heart and blood vessels at the same time.”

Image credit: ©stock.adobe.com/au/vege

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