Genetic malfunction triggers familial migraine

Monday, 06 July, 2020

Genetic malfunction triggers familial migraine

Neuroscientists have shed a new light on the mechanisms responsible for familial migraine, showing that a genetic dysfunction in specific brain cells of the cingulate cortex area strongly influences head pain occurrence. Their research has been published in the journal Science Advances.

Migraine is one of the most disabling disorders, affecting one in seven people and causing a tremendous social and economic burden. Several findings suggest that migraine is a disease affecting a large part of the central nervous system and characterised by a global dysfunction in sensory information processing and integration, which also occurs between migraine episodes (interictal period). For example, patients with migraine exhibit increased cortical responses to sensory stimuli during the interictal period. At present, the cellular mechanisms responsible for these alterations are largely unknown.

Neuroscientists at the University of Zurich (UZH), in collaboration with the University of Padua, have now identified a new mechanism implicated in a special form of migraine caused by genetic mutation. They report that this familial hemiplegic migraine type 2 (FHM2) causes a malfunction of astrocytes in the cingulate cortex, a brain region that is involved in the feeling of pain. Astrocytes, specific star-shaped brain cells, are essential contributors to neuronal function and have a strong impact on brain circuits and behaviour.

“Despite their abundance, astrocytes have been relatively overlooked by neuroscientists,” said study leader Mirko Santello from UZH — yet these cells are extremely important to clear transmitters released by neurons. The researchers were able to show that in familial migraine the astrocytes cannot remove excessive transmitters released by neurons.

“The impairment in astrocytic glutamate uptake in the cingulate cortex strongly enhances cortical dendritic excitability and thus enhances firing of the neurons,” Santello said.

Morphological reconstruction of a neuron of the cingulate cortex in a migraine episode. Image credit: UZH.

Furthermore, the study reported that the malfunction of the cingulate cortex also influences migraine occurrence. In a mouse model, the researchers showed that the mice displayed increased sensitivity to head pain triggers.

“By manipulating astrocytes in the cingulate cortex, we were able to reverse their dysfunction,” said UZH’s Jennifer Romanos, first author of the study. “This prevented an increase in head pain in mice carrying the genetic defect.”

Santello concluded, “Our results provide a clear example of how astrocyte dysfunction produced by a genetic defect affects neuronal activity and sensitivity to head pain triggers.” The findings help to better understand migraine pathophysiology and suggest that the cingulate cortex may represent a critical hub in the disease. The demonstration of the link between dysfunction of astrocytes in the cingulate cortex and familial migraine could help in devising new migraine treatment strategies.

Top image credit: © Rinder

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