Microbiome could help assess precancer risk in HPV patients
Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for progression to precancer, according to a study led by the Albert Einstein College of Medicine. Writing in the journal PLOS Pathogens, the study authors said their findings could lead to therapeutic strategies that manipulate the microbiome to prevent disease progression.
HPV infection is one of the most common sexually transmitted infections, and the causal agent of cervical cancer — but it is still not clear why only a small proportion of high-risk HPV infections progress to cervical cancer. To investigate the potential role of the cervicovaginal microbiome, researchers evaluated cervical samples from 273 women who had high-risk HPV infection and were participating in the Costa Rica HPV Vaccine Trial.
The team found that the abundance of Lactobacillus iners was associated with clearance of high-risk HPV infections. By contrast, Gardnerella bacteria were the dominant biomarker for progression of a high-risk HPV. Additional analyses revealed that the effect of Gardnerella is mediated by increased cervicovaginal bacterial diversity directly preceding the progression of a persistent infection to precancer.
The findings suggest that monitoring the presence of Gardnerella and the subsequent elevation in microbial diversity could be used to identify women with persistent high-risk HPV infection at risk for progression to precancer. If future studies support a causal role of the cervicovaginal microbiome and disease progression, then it might be possible to manipulate the cervicovaginal microbiome in a manner to activate a local immune response and prevent disease progression.
The study authors said they had prospectively demonstrated that “progression of a persistent high-risk HPV infection to cervical precancer is in part explained by unique features of the cervicovaginal microbiota”.
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