REM sleep regulates eating behaviour
Despite our broad understanding of the different brain regions activated during rapid-eye movement (REM) sleep, little is known about what this activity serves for. Researchers at the University of Bern have now discovered that the activation of neurons in the hypothalamus during REM sleep regulates eating behaviour, with their results published in the journal Proceedings of the National Academy of Sciences (PNAS).
During REM sleep, during which most dreaming occurs, specific brain circuits show very high electrical activity — yet the function of this sleep-specific activity remains unclear. Among the brain regions that show strong activation during REM sleep are areas that regulate memory functions or emotion, for instance. The lateral hypothalamus — a tiny, evolutionarily, well-conserved brain structure in all mammals — also shows high activity during REM sleep. Neurons from this brain region orchestrate appetite and the consumption of food when mammals are awake, and they are involved in the regulation of motivated behaviours and addiction.
Researchers headed by Prof Dr Antoine Adamantidis set out to investigate the function of the activity of hypothalamic neurons in mice during REM sleep, with the aim of better understanding how neural activation during REM sleep influences our day-to-day behaviour. They discovered that suppressing the activity of these neurons decreases the amount of food the mice consume, suggesting that REM sleep is necessary to stabilise food intake.
The researchers discovered that specific activity patterns of neurons in the lateral hypothalamus that usually signal eating in the awake mouse are also present when the animals were in the stage of REM sleep. To assess the importance of these activity patterns during REM sleep the research group used a technique called optogenetics, with which they used light pulses to precisely shut down the activity of hypothalamic neurons during REM sleep. As a result, the researchers found that the activity patterns for eating were modified and that the animals consumed less food.
“We were surprised how strongly and persistently our intervention affected the neural activity in the lateral hypothalamus and the behaviour of the mice,” said Lukas Oesch, the first author of the study. “The modification in the activity patterns was still measurable after four days of regular sleep.”
These findings suggest that electrical activity in hypothalamic circuits during REM sleep is essential to maintain a stable feeding behaviour in mammals. They also point out that sleep quantity alone is not solely required for our wellbeing, but that sleep quality plays a major role in particular to maintain appropriate eating behaviour.
“This is of particular relevance in our society where not only sleep quantity decreases but where sleep quality is dramatically affected by shift work, late-night screen exposure or social jet lag in adolescents,” said Prof Dr Adamantidis said.
The discovered link between the activity of the neurons during REM sleep and eating behaviour may help developing new therapeutical approaches to treat eating disorders. It might also be relevant for motivation and addiction. “However, this relationship might depend on the precise circuitry, the sleep stage and other factors yet to be uncovered,” Prof Dr Adamantidis said.
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