AdipoGen B-Xpander protein

Interest in B cells has recently increased, with immunotherapies using engineered B cells or tumour-infiltrating lymphocytes (TILs). However, current methods for B cell expansion are inefficient and time-consuming, and can lead to insufficient B cell numbers and persistent T cell exhaustion. AdipoGen’s B-Xpander protein is designed to improve current protocols for B cell stimulation by mimicking the natural interaction between CD40L and CD40 molecules on B cells.

The product is a potent enhanced multimeric human CD40L cytokine, suitable for B cell activation, B cell expansion (proliferation) and cell therapy applications. In-house production using a proprietary protocol and a characterised and certified CHO cell line allows the supply of active multimeric human CD40L proteins in GMP-like format. The product is available in standard grade, animal-free (AF) grade and certified serum grade (CSG).

Other features include: production in characterised and certified CHO cell line; high bioactivity tested by ELISA/cell-based assays; verified purity and homogeneity by SEC; low endotoxin levels; batch-to-batch consistency; animal-component free production; and no cross-linking reagents necessary.