AdipoGen Cystatin C (mouse) (monomer):Fc (silent) InVivoKine fusion proteins

Cystatin C (Cystatin 3) is a cysteine protease inhibitor involved in immune regulation and is widely expressed across tissues. Its expression is influenced by inflammation and infection, and it modulates immune responses by regulating cysteine protease activity.

Recent studies have identified Cystatin C as a potential therapeutic factor in Alzheimer’s disease. Secreted by peripheral tumour cells, it binds Aβ1–42 oligomers, activates the TREM2 receptor on microglia, enhances amyloid plaque clearance and improves cognitive function in mouse models.

InVivoKines are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines are Fc-based fusion proteins using the Knobs-into-Holes (KIH) technology. This Fc-KIH format allows the Cystatin C (mouse) (monomer):Fc (silent) InVivoKine protein to form a monomer Cystatin C fused to Fc, keeping its endogenous monomeric structure. The LALA-PG mutations (ie, ‘silent’) inhibit binding to FcγRs and C1q while FcRn binding and Fc stability remain unaffected.

AdipoGen Life Sciences’ Cystatin C (mouse) (monomer):Fc (silent) InVivoKine proteins are distributed in Australia and New Zealand by Sapphire Bioscience.