PacBio Vega benchtop system for HiFi sequencing

PacBio’s Vega benchtop system empowers scientists to manage sequencing projects in-house, removing batching bottlenecks and unpredictable project timelines by putting the user in full control from start to finish.

Powered by HiFi sequencing, the system is designed to consistently deliver accuracy of 99.9% or higher per run. The delivery of long reads with high precision should give researchers the confidence to explore complex biological questions.

Each run on the system includes real-time analysis of DNA methylation status using advanced deep learning algorithms. With integrated primary analysis, barcode demultiplexing and automatic conversion to BAM format, users will get fast access to meaningful data directly off the instrument.

The product encodes sequence data, quality scores and methylation information at just 0.5 bits per base, which should make it up to 20 times more efficient than other long-read platforms. Less storage facilitates faster analysis and more streamlined workflows.

The system enables researchers to generate reference-grade microbial genomes, resolve challenging repeat expansions, characterise full-length isoforms and assemble phased human genomes — all from a compact benchtop system. It has the ability to transform the lab into a centre of high-resolution genomic exploration, elevating sequencing projects and making HiFi sequencing more accessible.