Sartorius BIOSTAT STR Generation 3 bioreactor with BIOBRAIN automation platform

Wednesday, 11 March, 2020 | Supplied by: Sartorius Australia Pty Ltd

Engineered to address the rigorous requirements and complexity of biologics manufacture, Sartorius’s BIOSTAT STR Generation 3 bioreactor is a robust industrial platform consisting of hardware, software and consumables for single-use process development and commercial biomanufacturing. BIOSTAT STR bioreactors and Flexsafe STR bags range from 12.5 to 2000 L in working volume.

The system is powered by BIOBRAIN, an automation platform that gives biologics manufacturers the flexibility to quickly and easily configure the system to meet their precise needs. Data-driven software, a comprehensive suite of analytical tools and experienced engineering design and support teams enable manufacturers to produce consistent results, even in the setting of changing demands. The flexibility and responsive nature of the system deliver high quality and productivity for a stable, predictable process.

Fully integrated and redundant single-use sensors provide real-time data to measure and control key critical process parameters such as pH, DO, viable biomass, glucose, lactate and foam. Non-invasive measurements save set-up time, prevent interface issues and reduce the need for offline manual sampling. These monitoring and control systems are designed to enhance batch-to-batch consistency and operator confidence.

The bioreactor is ready for process intensification and includes functionalities such as feed controls, bleed controls and connectivity to Repligen’s XCell ATF cell retention devices to increase cell density and productivity. Connection to Umetrics SIMCA enables predictive, multivariate modelling and control, allowing manufacturers to predict yield and optimal harvest time points at the early stages of the perfusion process.

Integration into existing process infrastructure can be achieved in multiple ways: local management via the BIOSTAT STR control tower and BIOBRAIN automation platform with connection to data histories, or full process management via distributed control systems from Emerson, Siemens or Rockwell. An additional feature is the optional integration of native Emerson DeltaV controls supported by a Sartorius DeltaV library, which affords full access and control from DeltaV systems.

Phone: 03 8762 1800
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