Researchers identify signals triggering dendrite growth

A team of researchers from the Queensland Brain Institute (QBI) has probed the molecular mechanisms which prompt the development of dendrites, in the nematodeCaenorhabditis elegans.

Dendrites are the branch-like structures in nerve cells which receive electrochemical signals from other nerve cells or sensory inputs from the external environment.

Along with the cable-like structures called axons, which transmit electrical impulses between neurons, dendrites are crucial to nervous system function, but their development has been poorly understood to-date.

The QBI team has discovered that a ligand called LIN-44 and a receptor called LIN-17 work together to coax certain neurons in C. elegans to extend dendrites towards their targets.

“This is the first study to demonstrate, in vivo, that the initial outgrowth of a dendrite is controlled by these ligands and receptors,” said Leonie Kirszenblat, the research assistant who carried out the study in Dr Massimo Hilliard’s lab.

Understanding these fundamental mechanisms of neuronal development may have practical, as well as theoretical implications.

“Having the ability to control dendritic growth may be important for growing neurons from stem cells, which could be useful in a range of neurologic conditions, including spinal injury,” said Dr Hilliard.

The findings were published in the latest issue of PLoS Biology.