Millennium Science is a specialist distribution company established in 1999 and is a solution supplier to the science industry with a core competency in the delivery of high technology products. These include hardware, software and consumables. Millennium Science focuses heavily on pre- and post-sales technical support and employs scientifically qualified Technical Sales Representatives in each state backed up by PhD qualified Application Scientists and a team of highly experienced Service Engineers and customer service and support staff.
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Unit 2, 390 Canterbury Road , Surrey Hills VIC 3127 (Directions)
The Pacific Biosciences third-generation PacBioRS DNA sequencing system incorporates novel, single-molecule sequencing techniques and advanced analytics to reveal biology in real time using its SMRT technology.
The EVOS xl core inverted microscope from Advanced Microscopy Group is claimed to provide fast, easy and affordable microscopy and can be used for cell culture work.
BioTek continues to provide enhanced microplate reader control, data processing and export flexibility with the launch of Gen5 Version 2.0 Data Analysis Software. A new interface combines ease of use and memorable visuals with power and flexibility for increased productivity.
BioTek’s monochromator-based Eon microplate spectrophotometer combines high performance and value in microplate-based absorbance readings.
BioTek Instruments has launched the ELx405 Select Deep Well Washer, a robot-compatible, full plate washer for automated aspirate and dispense steps in 96- and 384-well plates up to 50 mm high. It can also accommodate standard 15 mm microplates and delivers increased washing efficiency compared to manual and handheld methods.
TTP LabTech’s acoustic biosensor, Libra2, can be used for the study of glycosylation patterns on cell membranes.
Adenosine 3′, 5′ cyclic monophosphate (cAMP) plays a critical role in the transmission of signals by functioning as a ‘second messenger’. Binding of hormones or ligands to their respective receptors can either inhibit or enhance the production of cAMP by changing the activity of the enzyme adenylate cyclase. Adenylate cyclase is a membrane-associated enzyme that catalyses the formation of cAMP from ATP. Intracellular cAMP levels, in turn, regulate enzymatic activity of numerous protein kinases, which phosphorylate specific targets setting off a cascade of cellular events. Because of the importance of cAMP as a cellular messenger, several different reading methodologies have been developed to measure cellular levels, one of which is AlphaScreen. Here we describe and demonstrate the ability of the Synergy 2 to quantitate cAMP using this methodology.
Nucleic acids isolated from a variety of sample types such as animal models, body fluids or eukaryotic and bacterial cells provide the starting material for a broad range of downstream applications including gene expression, genotyping, sequencing and cloning. Quantification of isolated nucleic acid is necessary prior to introduction into these applications. The Epoch Spectrophotometer System provides a means of obtaining accurate measurement over a wide range of sample concentrations and volumes, including microvolume quantification. Comparison to other microvolume dedicated devices, such as NanoDrop, shows equivalent performance.
AKT is a serine/threonine protein kinase that plays a key role in cellular processes. AKT has become a popular target for drug discovery campaigns, due to the fact that AKT inhibitors may help to treat a number of cancers. BioTek has demonstrated an automated homogeneous assay to probe AKT phosphorylation at its serine 473 residue using endogenous levels of kinase expression within human primary HUVEC cells.
Cytokines and growth factors are cell signalling proteins that mediate a number of physiological responses. In addition, they are also associated with a number of diseases including tumour growth and metastasis, infections and inflammation. Because these molecules rarely act unilaterally it is important to assess a number of them in parallel. The advent of multiplex assays using Luminex xMAP bead technology has simplified the task of performing multiple assays on samples. BioTek has demonstrated how to automate the wash steps of the Bio-Rad HumanCytokine 8-plex assay kit using the ELx405 Magnetic Bead Washer.
The Amnis FlowSight is a compact and affordable 12-channel flow cytometer with good fluorescence sensitivity and the ability to produce imagery of every cell.
The Thermo Scientific Cellomics CellInsight is a cost-effective benchtop personal cell imager designed for researchers requiring automated, quantitative imaging of cells for the first time or those who need more scalability of their existing high-content imaging assays.
Current next-generation sequencing (NGS) workflows have numerous manual processes that bottleneck throughput and contribute to process inefficiency. One of the most time-consuming tasks is gel-based size selection during the library-generation process. In addition to being labour intensive and not scalable, manual methods introduce run-to-run and operator-to-operator variability. Furthermore, the imprecision of this manual excision results in the size selection precision (width of the selected band) being typically no better than ±10% of the median fragment size (eg, 400 bp ± 40 bp).
QuantiGene cancer and disease research assay kits enable direct quantification of miRNA, mRNA or DNA targets directly from any sample. They are based on the branched DNA (bDNA) signal amplification technology used in Siemens’ FDA-approved Versant assays for HIV and Hepatitis C viral load testing.
The LabChip GX is an accurate and advanced nucleic acid separations system. Like its predecessor the LabChip90, the GX suite of instruments uses Caliper’s microfluidics technology to perform reproducible, high-resolution, eletrophoretic separations.
The CellInsight personal cell imaging (PCI) platform has been added to the Thermo Scientific Cellomics high-content screening. It can be used for high-content analysis and cellular imaging technology.
The Take3 multivolume plates can be used to perform absorbance measurement over a wide range of applications and sample volumes in a BioTek microplate reader.
The Axiom genotyping solution from Affymetrix can be used for genome-wide association studies (GWAS) and candidate gene association studies.
G-protein coupled receptors (GPCRs) are an important protein family in pharmacological applications and drug discovery research as they are involved with many critical cellular signalling responses. Monitoring the response of GPCRs to a variety of agonist and antagonists is currently being investigated by academic researchers and drug discovery efforts. Traditionally, methods in cAMP quantification require cell lysis prior to detection of intracellular cAMP levels with a colorimetric readout. This method was improved by increasing sensitivity using methods such as TR-FRET and bead-based assays, though they were considered end-point assays and still required cell lysis prior to detection.
Millennium Science offers a range of products to improve efficiency throughout select stages of the next-generation sequencing (NGS)workflow, no matter which NGS platform used.
BioTek’s MultiFlo microplate dispenser uses multiple technologies to dispense multiple reagents into multiple microplate types. This all-in-one dispenser saves bench space and transfer time and also eliminates plate set-up steps, thus simplifying the dispensing process.
BioTek has released the Synergy H1 hybrid multimode microplate reader which expands the performance, versatility and flexibility offered by hybrid technology.
The Odyssey Fc Imager is claimed to be the first CCD imager to provide infrared (IR) fluorescent and chemiluminescent imaging performance in one system. The optical system combines solid-state laser diodes at 685 and 785 nm with a low-noise, CCD camera for detection of IR and chemiluminescent signals.
TTP LabTech’s mosquito LCP liquid handler is a dedicated device that has been designed to facilitate the crystallisation of membrane proteins, such as G-protein coupled receptors, by offering a fully automated solution to lipid cubic phase (LCP) screening. It incorporates an auto-homing positive displacement syringe for the accurate and repeatable dispensing of LCP in addition to the standard disposable, positive displacement mosquito tips that are claimed to eliminate zero cross-contamination. This novel automation system enables LCP screening to be performed accurately and with ease and increases the throughput of crystallisation set-ups.
SoftGenetics has added a bar-code tool to its second-generation sequence analysis software, NextGENe. The software allows biologists to analyse the vast amount of data generated by next-generation sequencing systems using preprogrammed applications, an easy-to-use interface and algorithms, and quickly process the sequence and quality files on standard Windows 64-bit operating system hardware.
The Essen IncuCyte system provides continuous, time-lapse images of live cells from within users’ standard cell-culture incubators. Users program the system to acquire images at different spatial locations and time points via a network-accessible graphical user interface. The system then automatically focuses on each spatial location and acquires the successive images automatically, around the clock.
TTP LabTech has announced the Mirrorball, a high-sensitivity, laser-scanning microplate cytometer for antibody discovery. Developed by an in-house team, the cytometer is set to fill a role in the antibody discovery process by rapidly and reliably performing mix-and-read, cell- or bead-based assays. In essence, this instrument offers a simple and easy solution to automated hybridoma screening and will not require the reworking of existing protocols.
The Li-Cor Pearl impulse imager provides real-time imaging and allows near-infrared labelled compounds with low diffusion coefficients to be visualised as they distribute to various regions of the body.
The Amnis ImageStreamX imaging flow cytometer, with second-generation ImageStream technology, combines the speed, sensitivity and phenotyping abilities of flow cytometry with the detailed imagery and functional insights of microscopy.
The Evos range of high-resolution imaging systems from AMG allows users to view, capture and archive images of specimens in various culture vessels and on slides.
BioTek’s Epoch multi-volume spectrophotometer system is designed for a wide range of applications, from nucleic acid and protein quantification on a micro scale to cell-based assays in microplates, BioCells or standard cuvettes.
As part of its genomics portfolio, Golden Helix provides an analysis suite that is compatible with most platforms, including Affymetrix.
BioTek’s Synergy H4 Hybrid Microplate Reader has received Transcreener approval from BellBrook Labs. The approval extends to the Transcreener Fluorescence Polarisation, Far Red, Red Fluorescence (FI) and Red TR-FRET assays and means that the Synergy H4 meets strict standards in instrument set-up and assay performance.
The BioTek EL406 1536-well microplate washer offers good performance with a range of options for varying requirements.
Protein Forest has developed digital Proteome Chip (dPC) technology that fractionates and concentrates proteins or peptides by isoelectric focusing for mass spec analysis and western blotting.
The digital ProteomeChip (dPC) developed by Protein Forest for mass spec sample preparation is available from Millennium Science.
Millennium Science has introduced the Accuri C6 flow cytometer, said to be affordable, powerful, simple and automated.
BioTek Instruments’ Synergy Mx Monochromator-based Microplate Reader has been DLReady certified for dual-luciferase assays. This certification establishes the Synergy Mx as meeting the performance levels and standards for Promega’s Dual-Luciferase Reporter (DLR) Assay System - a widely used luminescence-based assay for measuring gene transcription and control in microplate format.
The Li-Cor Odyssey Infrared Imaging System sweeps away the old paradigms of chemiluminescence and visible fluorescence and introduces a new standard for Western blot analysis - direct infrared fluorescence detection.
BioTek Instruments has expanded its ELx405 Microplate Washer product line with the ELx405 Magnetic Bead Washer. Developed in conjunction with genotyping, gene expression and protein assays that are built on Luminex Corporation’s xMAP platform, the ELx405 Magnetic Bead Washer offers high-strength biomagnetic separation in both 384- and 96-well microplates.
The Synergy Mx Monochromator-Based Multi-Mode Microplate Reader is the newest addition to the Synergy family from BioTek.
The BioMark & EP1 systems from Fluidigm combine instrumentation, arrays and software to provide the scientist with a powerful tool.
The next-generation Affymetrix Cytogenetics Research Solution includes arrays, reagents and analysis software for the detection of a broad range of chromosome aberrations affecting phenotypes.
Affymetrix has launched the next-generation Affymetrix Cytogenetics Research Solution which includes arrays, reagents and analysis software for fast and reliable discovery and detection of chromosome aberrations.
BioTek Instruments has released Gen5 version 1.08.4 of its Microplate Data Analysis Software which provides new features to enhance enterprise-wide user management and system notifications.
The GeneChip miRNA array from Affymetrix is a powerful tool for studying the role of microRNAs (miRNAs) and their importance in cancer and other diseases and the discovery of biomarkers and disease signatures.
Amnis has released an Extended Depth of Field (EDF) upgrade for its ImageStream imaging flow cytometer.
The Precision XS Microplate Sample Processor combines a single-channel sample processing head, an 8-channel pipetting head and an 8-channel bulk reagent dispenser into one compact product.
The EL406 Microplate Washer Dispenser offers fast and full microplate washing along with both peristaltic and microprocessor-controlled syringe drive reagent dispenser technologies. The system helps optimise liquid handling processes in microplate format, including complex wash routines.
The ELx405 microplate washer offers several options for processing 96- and 384-well microplates to meet all throughput requirements.
BioTek Instruments has announced a software tool for clinical laboratories using the ELx800 and ELx808 microplate readers. Gen5CL Data Collection and Analysis Software combines the convenience and security of preprogrammed clinical diagnostic assays with the power and flexibility of a PC-based application. The PC-based interface provides greater flexibility in data analysis and output options than onboard microplate reader programs, including LIS system compatibility and data/protocol storage.
The monochromator-based Synergy Mx multimode microplate reader provides reliable performance in fluorescence, luminescence and absorbance read modes.
BioTek Instruments has incorporated parallel line analysis into the Gen5 Data Analysis Software version 1.06. Parallelism analysis can be made with Gen5’s linear regression, 4- and 5-parameter logistic fits.
BioTek Instruments has announced a software tool for clinical laboratories using the ELx800 and ELx808 microplate readers.
Affymetrix has released its Cytogenetic Solution, combining the high-density SNP array 6.0 with a simple assay and intuitive software that provides cytogeneticists with an accurate method of detecting chromosomal abnormalities associated with congenital diseases such as autism and mental retardation.
The PowerWave microplate spectrophotometers combine a monochromator-based optical system with hardware and software features designed to meet a variety of microplate-based applications. The readers allow the user to either scan across selected wavelengths or select a discrete wavelength (in 1 nm increments) across the UV-Vis range.
Affymetrix has released the GeneChip Human Gene 1.0 ST Array, the latest addition to its Whole-Transcript (WT) assay-based gene expression product family. With the Human Gene 1.0 ST Array design, each of the targeted 28,869 genes is interrogated by an average of 26 probes targeting exon content spread across the entire length of each gene.
The Twister II advanced microplate handler is more than a high-capacity plate stacker, it's a plug-and-play benchtop automation solution.
The Molecular Devices SpectraMax M5 is a five mode microplate reader with three mode cuvette port. It is a dual-monochromator, multi-detection microplate reader which features a triple-mode cuvette port and single-read command capability for experiments requiring multiple detection parameters. Using two scanning monochromators, the system also provides users with the flexibility to choose any wavelength between 200 and 1000 nm. The instrument uses standard microplates (6 to 384 well) to read endpoint, kinetic, spectrum, multi-wavelength and well area scanning.
The emergence of genomic and proteomic research has created a need for a more effective way to generate and analyse data.
The QPix2xt automates to front-end multi-stage process of generating expression clones in bacterial and other systems.
The Embla 96/384-well washer from Molecular Devices is a top-loading, robotic-compatible plate washer for 96- and 384-well microplate washing. It is suitable for ELISAs and most cell applications.
Molecular Devices has developed FlexStation, a scanning microplate reader and fluidics transfer workstation that allows users to obtain real-time kinetic data milliseconds before and after fluid transfer events. The ability to perform microplate-to-microplate transfers, prompt kinetic reads and multi-wavelength detection options offers flexibility for drug discovery or research efforts.
Theonyx is an automation platform developed by MWG Biotech in partnership with Sias AG. Theonyx is characterised by flexibility as the system's modular set-up allows the combination of a multitude of functions on just one robot. Liquid handling dynamics are driven by a micro annular gear pump mechanism within the robot arm itself. For the user this means a dynamic range of less than 1 µL up to more than 3 mL, within a single pipetting action, and without compromises in accuracy or precision.
MWG-Biotech's laboratory robot, RoboSmart, can completely automate, in one single step on one single robot platform, plasmid or PCR product purification, setup, processing, and subsequent purification of the sequencing reaction.
MWG-Biotech has launched the Pan E.coli Array. All 4.289 genes of the bacterium are represented on the array using MWG-Biotech's 1 gene/1 oligo method, where each bioinformatically designed HPSF oligonucleotide is 100% gene specific and thus guaranteed to identify the gene it was produced for. The organism used for MWG-Biotech's Pan E.coli Array is the strain K12, a non-pathogenic standard research organism. MWG-Biotech will soon introduce a modified version of the Pan E.coli Array to study pathogenic (disease-causing) effects of micro-organisms in detail. For this a combination of genes of E.coli K12 with about 1.200 additional genes of the pathogenic haemorrhagic (causing intestinal bleeding) E.coli strain 0157:H7 will be used. E.coli 0157:H7 has recently received public attention in food poisoning cases involving raw meat and apple juice.