Xeno-free Recombinant Human Activin A from HumanZyme is a member of the TGF beta superfamily, expressed from human 293 cells as disulfide-linked homodimer with an apparent molecular mass of 25 kDa.
GeneCopoeia offers premade cancer cell lines carrying diverse gene mutations commonly seen in tumour biomarkers, including EGFR, KRAS and BRAF in the MAPK pathway.
HumanZyme has developed the HumaXpress human cell expression system, which produces authentic recombinant HumanKine proteins with correct post-translational modifications, subunit assembly, folding, secretion and stability.
The osteomiR microRNA signature is intended to assess the risk of a first fracture in female patients of postmenopausal osteoporosis and type 2 diabetes. This information enables timely interventions and can help to avoid fractures.
GeneCopoeia's Genome-CRISP CRISPR-Cas9 products and services are designed to provide a complete, powerful solution for precision RNA-guided genome editing.
GeneCopoeia's AAVPrime adeno-associated virus (AAV) products are useful tools for inserting genes into a broad range of cell types with high efficiency and enhanced safety.
NECi offers enzymes and enzyme-based test kits for the analysis of nitrate and phosphate in the laboratory or out in the field.
The Abraxis Glyphosate strip test is a rapid immunochromatographic test designed solely for use in the qualitative screening of glyphosate in water and food samples.
Enzo Life Sciences' high-sensitivity, low-background reagent range includes the POLYVIEW PLUS HRP (anti-rabbit), POLYVIEW PLUS HRP (anti-mouse) and POLYVIEW PLUS AP (anti-rabbit) reagents.
The versatile set of anti-histone monoclonal antibodies offered by Cosmo Bio is a valuable addition to any lab's epigenetic toolbox.
Applied BioProbes offers the LIVE-or-DIE cell viability assay for yeast, animal and bacterial cells. The kit is designed to enumerate the proportion of live and dead cells in a population.
GeneCopoeia HDR donor clones and cloning vectors enable many CRISPR applications, such as precisely defined gene knockout, in-frame fusion tagging, transgene insertion and the introduction of base pair changes for mutagenesis or disease correction.
The DRAQ5 Fluorescent Probe, from Applied Biosciences, is a far-red DNA stain for fluorescent cellular imaging applications with live or fixed cells.
GeneCopoeia carries a comprehensive suite of premade stable cell lines. Each of the stable cell lines is provided in a number of widely studied cancer cell lines, providing useful tools for studying cancer properties and development of effective therapies.
ExProfile Pathway Gene qPCR Arrays from GeneCopoeia profile the expression of pathway-related genes, which are carefully chosen for their close pathway correlation based on a thorough literature search of peer-reviewed publications.
miTarget miRNA 3′ UTR target clones from GeneCopoeia are designed for mammalian miRNA target identification and functional validation of predicted targets. Target clones are also used to study the regulatory effect of miRNA on target gene(s).
AbraMag Magnetic Beads from Abraxis are super-paramagnetic, non-aggregating iron oxide particles (or 'microspheres') for sample prep or for capturing/purifying targets such as proteins, antibodies, DNA/RNA and E. coli
VECELL gas-permeable plates from Cosmo Bio consist of a hybrid of a high-porosity membrane and gas-permeable membrane. Oxygen can be supplied from the bottom of the wells, providing a close to in vivo condition for cell culture.
The Total PSA ELISA kit, from Enzo Life Sciences, enables the detection of total PSA in human serum, plasma, urine and tissue culture media samples in just 2.5 h for up to 40 samples in duplicate.
Anti-Müllerian hormone (AMH) is a member of the TGF-β family of genes and has been shown to be present in both males and females. AMH (human), (recombinant) is now available commercially from Enzo Life Sciences.
The AMPIPROBE HCV assay kit, from Enzo, is a quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay for the detection of human hepatitis C virus (HCV) RNA in plasma or serum.
With optimised reagents, Enzo's CYTAG CGH Labeling Kits produce high-quality data using as little as 0.25 µg of genomic DNA. The kit contains the restriction enzymes AluI and RsaI, plus PCR and gel clean-up columns.
The LDH Cytotoxicity WST Assay is a colorimetric assay kit used to determine cytotoxicity by measuring lactate dehydrogenase activity released from damaged cells.
Enzo's DIG-labelled nucleotides can be used to make low background nucleic acid probes which can be used downstream for a variety of molecular biology applications.
Enzo's FLUOFORTE Calcium Assay Kits detect mobilisation of intracellular calcium utilising a fluorogenic calcium-binding dye optimised for good cell permeability and retention. Developed for use with conventional dual-dispensing microplate readers, the kits provide EC50 values comparable to Fluo-4 and Calcium 4.
MédiMabs offers a rabbit antibody that acts as an immunohistochemical alternative to existing staining systems, suitable for use with mouse (MAP) or rat (RAP) primary antibodies.
Enzo's PROTEOSTAT Aggresome Kit provides a sensitive cell-based assay of drug responsiveness to identify inhibitors relevant to neurodegenerative disease in an authentic cellular context. It easily quantifies aggresome and related inclusion bodies by flow cytometry.
The Insulin ELISA Kit, from Enzo Life Sciences, enables the detection of insulin in serum, plasma and tissue culture media. The kit is suitable for a variety of research areas, including diabetes mellitus, hypoglycaemia, impaired glucose tolerance, insulinoma, metabolic syndrome and polycystic ovary syndrome.
Cosmo Bio's PUREfrex kit is a reconstituted cell-free protein synthesis reagent based on PURE system technology. The reaction system consists of proteins, ribosomes, amino acids and NTPs.
The Enzo Life Sciences TIMP-1 (human) ELISA kit enables sensitive measurement of TIMP-1 in just 2 h, detecting as little as 30 pg/mL. There is negligible cross reactivity with similar proteins and its high-throughput format is suitable for up to 39 samples in duplicate.
The Enzo Life Sciences human growth hormone ELISA kit enables detection of HGH in serum, plasma, saliva and tissue culture media in just 2.5 h, detecting as little as 0.93 pg/mL. There is negligible cross reactivity with similar proteins (eg, prolactin, human palcental lactogen) and its high-throughput format is suitable for up to 36 samples in duplicate.
The Enzo Life Sciences Proinsulin ELISA kit enables detection of proinsulin in human serum and plasma samples in 3 h, detecting as little as 0.17 pM. There is negligible cross reactivity with insulin and its high-throughput format is suitable for up to 40 samples in duplicate.
The Elastin Glycation Assay Kit, from Cosmo Bio, is a complete assay system designed to measure the fluorescent advanced glycation end products (AGEs) formed in elastin.
The FLOWSCRIPT HPV E6/E7 Assay Kit from Enzo Life Sciences is a flow cytometry-based assay for the detection of E6/E7 mRNA in whole cells. The assay employs an in situ hybridisation technique utilising a cocktail of probes specific to multiple targets within the E6 and E7 genes.
Enzo Life Sciences provides a complete colorimetric assay kit for measuring cellular calcineurin phosphatase activity. It employs a convenient 96-well plate format with all reagents necessary for measuring calcineurin phosphatase activity in tissue/cellular extracts.
PD-1 (programmed cell death-1), also known as CD279, is a transmembrane protein important for regulating immune responses. Human recombinant PD-1 is now available from Enzo Life Sciences in 50 µg packs.
The Luc-Pair Luciferase Assay Kit 2.0 kit is optimised for long-range linearity of both firefly and Renilla luciferase signals. It is suitable for studying the interaction between precursor miRNA clones and miTarget 3'UTR target clones.
The Transferrin ELISA kit from Enzo Life Sciences is used for the quantitative determination of transferrin in human serum, human plasma and canine serum. Applications include researchers working in anaemia, haemochromatosis (iron overload), cirrhosis and non-alcoholic fatty acid liver disease.
Cosmo Bio's Fertiup and Card Medium are high-performance media for mouse sperm cryopreservation, sperm preincubation and in vitro fertilisation (IVF). When used in combination, the products provide a high and stable fertilisation rate using frozen-thawed mouse sperm.
The Cell Counting Kit-8 is a sensitive colorimetric assay for the determination of the number of viable cells, using WST-8, in cell proliferation and cytotoxicity assays.
Enzo Life Sciences introduces the BioArray Single-Round RNA Amplification and Biotin Labeling System for microarrays. The system decreases experimental variation and standardises biological data derived from microarrays to allow for correlation of results from experiment to experiment.
GeneCopoeia offers Genome-CRISP CRISPR human single guide RNA (sgRNA) libraries which consist of sets of single guide RNAs (sgRNAs) cloned into lentiviral vectors for dual-use (transfection or transduction) delivery methods.
Enzo Life Sciences offers Eicosanoids ELISAs for direct measurement of LTB4, PGE2 and TXB2 for use in a number of sample types including mucosa, tissue, serum, plasma, urine and much more. Cited in peer-reviewed literature, the ELISAs offer ultrasensitive measurement at the pg level.
Understanding why cells undergo senescence (biological ageing) and how it can affect complex biological processes is an important research area. Enzo Life Sciences offers a broad range of products for ageing research.
Enzo Life Sciences' Mito-ID Membrane Potential Cytotoxicity Kit measures fluctuations in mitochondrial membrane potential (MMP) by utilising a cationic dual-emission dye. Cells exhibit a shift from orange to green fluorescence as mitochondrial function becomes increasingly compromised.
Enzo Life Sciences offers two solutions to eliminate DNA contamination from PCR mastermixes and RNA preps.
The Enzo Life Sciences Diglycyl Lysine, mAb (GX41), is a highly specific monoclonal for ubiquitin remnant profiling that recognises the diglycyl-lysine residue left behind after the ubiquitin itself is long gone - with no detectable reactivity to non-modified lysines.
Innova Biosciences has launched the latest antibody and protein labelling kits within its Lightning-Link Rapid range. The company has released its high-sensitivity Atto dyes and Cy dyes, as well as a rapid biotin conjugation kit which allows for quick protein biotinylation.
ExProfile Pathway Gene qPCR Arrays from GeneCopoeia are easy-to-use tools to study pathway- or disease-related gene expression profiling. All primers are experimentally validated and optimised in a real-time PCR condition.
Enzo Life Sciences' Mito-ID assays work together to assess the dynamic interaction between mitochondrial respiration and glycolytic flux.
SuperFasLigand is soluble, human and recombinant. It is said to provide enhanced immune activation compared to other recombinant ligands. The product features an N-terminus linker shown to improve stability and mimics glycosylation of native human FasL.
Enzo Life Sciences offers a complete portfolio of products for water testing, including high-purity microcystin analytical reference standards (≥99%) and numerous microcystin analogs.
The Screen-Well Nephrotoxicity Library from Enzo Life Sciences is a focused collection of compounds with defined and diverse nephrotoxicity, including analgesic nephropathy, interstitial nephritis, glomerularopathy, proximal and distal tubulopathy, acute renal failure, chronic kidney disease and more.
Enzo Life Sciences offers a comprehensive line of research tools for the complete isolation of SUMOylated proteins. SUMOylation of target proteins is involved in a range of cellular processes such as nuclear protein targeting, formation of sub-nuclear complexes, regulation of transcriptional activities and control of protein stability.
The Chemilum de Lys HDAC/SIRT Chemiluminescent Drug Discovery Kit enables reproducible, high-throughput screening of HDAC or SIRT inhibitors using a novel substrate that closely mimics the natural in vivo substrate.
Aves Labs chicken-produced neural cell marker antibodies can be used along with existing mouse or rabbit antibodies in double-labelling studies. The neuronal cell markers are made against sequences that are 100% shared between mouse and human proteins, ensuring that the neural cell marker antibodies will react with a wide range of different mammalian species.
The primary cilium acts as a sensory organelle that transfers information from the environment to the cell interior. Proteintech has over 70 antibodies recognising cilia-related proteins.
The Amp'd GLP-1 ELISA kit, from Enzo Life Sciences, enables the ability to use less sample to detect levels of human Glucagon-like peptide 1 (7-36) amide: a potent promoter of insulin secretion which is a major incretin hormone and therapeutic for type 2 diabetes.
Enzo Life Sciences has introduced a novel line of conformational ELISA kits providing a sensitive, systematic and robust measurement of biosimilar conformation comparability at the molecular level. The kit allows for 3D conformational comparison and higher-order structure (HOS) characterisation between biosimilars and marketed MAbs.
The CRP (human) ELISA kit from Enzo Life Sciences is a complete, colorimetric, competitive immunoassay kit for the quantitative determination of human CRP in serum and plasma.
The cortisol ELISA kit from Enzo Life Sciences can be used with a large variety of sample types and produces highly reproducible results for stress, autoimmune disease and cancer research.
Enzo Life Sciences CD marker antibodies are available to identify various features and isolate the user's target. Available in either a standard or conjugated format to a variety of detection agents, they can help researchers visualise, identify, purify and target immune cells and tissues that display CD markers on their surfaces.
Improving the product development cycle for new therapies is a constant challenge for drug discovery researchers. With the DiSH kit, Enzo Life Sciences provides a tool to enable rapid detection and production of highly specific monoclonal antibodies.
Exendin-4 is a 39 aa polypeptide and incretin mimetic which was first isolated from Gila monster saliva. The synthetic form, Exenatide, is a glucagon like peptide-1 (GLP-1) agonist approved for the treatment of diabetes mellitus type II.
A notable feature of Mebiol Gel is its temperature-reversible sol-gel transition. When cooled, the product handles like a liquid, but becomes a rigid hydrogel at higher temperatures. In practice, this means easy cell handling.
Cosmo Bio announces AteloGene, a tool for delivering siRNA into animal tissues by local or systemic administration in mice and then efficiently introducing it into the cells.
Adiponectin controls many metabolic processes and is known to contribute to metabolic pathologies, including diabetes, atherosclerosis and obesity. AdipoRon is a novel small molecule that mimics adiponectin.
The AmpiGene Taq Mixes and RT-PCR Kit from Enzo Life Sciences are optimised to provide simple solutions for PCR experiments. The range comes in a variety of flexible formats to enable easy PCR and RT-PCR.
CloverDirect tRNA reagents from Cosmo Bio, for site-directed protein functionalisation, allow the incorporation of unnatural amino acids at defined positions of proteins using in vitro translation.
MegaCD40L from Enzo Life Sciences is an optimised soluble human CD40L oligomer, composed of two CD40L trimers joined via self-assembling chimeric domains.
GeneCopoeia offers services for establishing stable cell lines for protein overexpression, gene knockdown or genome editing which meet the user's specific research needs.
NT-proBNP brain natriuretic peptide, a member of the cardiac natriuretic hormones (CNHs) family, is secreted by the hemodynamically stressed heart, mainly in response to myocardial stretch induced by volume overload. The NT-proBNP ELISA from Biomedica provides reproducible results with an easy-to-use, convenient 96-well protocol (5 standards, 1 control).
The Biotherapy Institute of Japan has released the Binkit for NK cells expansion from PBMCs. A benefit of the kit includes the ability to expand natural killer (NK) cells from human peripheral blood mononuclear cells (PBMCs) without the need for feeder cells.
Enzo Life Sciences has introduced an ELISA kit to quantify trefoil factor 1 in a wide variety of sample types - including bronchoalveolar lavage fluid, plasma or serum - for immunity and inflammation research.
Westase, manufactured by Ozeki Corporation in Japan, is prepared from the liquid culture supernatant of Streptomyces rochei
DB-34. The product has complex lytic activity in yeast cells mainly consisting of -1,6 glucanase and -1,3 glucanase activity.
The Blood and Tissue DNA methylation kit from Enzo Life Sciences features simple DNA bisulfite conversion directly from blood, tissue and cells without the prerequisite for DNA purification. The sensitivity of the kit makes it possible to amplify bisulfite converted DNA from as few as 10 cells or 50p g DNA.
Cosmo Bio has introduced Easy-Western (EZW), a primary antibody detection reagent kit for Western blots. The kit is based on multi-antibody detection (MAD) technology.
The MultiView Universal Tissue Microarray from Enzo Life Sciences consists of 11 human tissue specimens - including placenta, liver, tonsil, colon, skin, brain, breast (fibroadenoma), prostate, thyroid, kidney and fallopian tube - for a broad spectrum of immunohistochemical staining procedures.
Enzo Life Sciences has expanded its portfolio of Wnt Pathway assays with the Leading Light Sclerostin-LRP Screening System. The simple, rapid biochemical binding assay format does not require cell lines or transfection reagents.
The Enzo Life Sciences Screen-Well FDA-approved drug library has been revised to provide over 100 more compounds, including recent FDA-approved drugs, making it a complete option for drug repurposing screens.
Enzo Life Sciences' GFP-certified Nuclear-ID Red Cell Cycle Analysis Kit provides a convenient approach for studying the induction and inhibition of cell cycle progression by flow cytometry.
Cosmo Bio has launched the rat/mouse surfactant protein D (SP-D) sandwich ELISA, which measures the concentration of rat/mouse SP-D using two monoclonal antibodies against rat SP-D.
LifeSensors has added several small molecule ubiquitin ligase and proteasome inhibitors to its range.
The Cyto-ID Autophagy Detection Kit from Enzo Life Sciences measures autophagic vacuoles and monitors autophagic flux in live cells using a novel dye that selectively labels autophagic vacuoles.
LifeSensors’ E2 Select Profiling & Selection Kit allows the exploration of functional competency between an E3 ligase of interest across a panel of 24 E2 conjugating enzymes.
Enzo Life Sciences offers a broad range of native bacterial and viral antigens for the research and in vitro diagnostics markets. Wherever practical, the antigens are isolated and purified from culture. In cases where antigen yield may be very low, the antigens are produced using the latest mammalian expression systems.
Tandem Ubiquitin Binding Entities (TUBEs) are high-affinity ‘ubiquitin traps’ that bind polyubiquitin chains. LifeSensors has developed TUBE technology for the detection, characterisation and isolation of polyubiquitylated proteins from cells and tissue extracts.
The D-Serine Colorimetric Assay Kit from Cosmo Bio employs the D-form specific enzyme D-serine dehydratase from Saccharomyces cerevisiae
(DsdSC), enabling the quantitation of D-serine by spectrophotometric measurement.
Genome-TALER Human AAVS1 Safe Harbor Knock-in ORF Clones from GeneCopoeia are constructed for specifically transferring the ORF of interest from a donor plasmid into the AAVS1 safe harbour site in human chromosome 19 using the Genome-TALER Human AAVS1 Safe Harbor Gene Knock-in Kit.
The Hanby TPH Field Test Kit system is a field-portable method providing rapid analyses down to ppb for aromatic compounds, including gasoline, diesel, PCBs and many others. The procedure extracts the aromatic compounds from the sample and provides immediate colorimetric identification of the concentration and type of contaminants present.
The Enzo Life Sciences Corticosterone & Cortisol ELISA kits are colorimetric, competitive immunoassay kits optimised to quantitatively determine sample levels in culture supernatants, faeces, plasma, serum, urine and saliva from any species.
With a rapid assay time and easy-to use protocol, the Enzo 25(OH) Vitamin D ELISA Kit (ADI-900-215) has a rapid assay time of just 1.5 h for up to 40 duplicates or 80 single samples.
Recent studies indicate high-molecular weight (HMW) adiponectin oligomers result in the most biologically active form of the protein. Recombinant Human Adiponectin from Enzo Life Sciences has been shown to have several advantages.
LifeSensors’ SUMO-based expression systems maximise the yield of soluble, functional proteins in E. coli
, yeast, insect and mammalian cells.
vPair antibodies from Abiocode represent a pair of fully characterised antibodies that recognise two different regions of a target protein. The product was developed to address whether the signal observed truly represents the protein of interest, an often encountered issue in antibody-based assays.
The Thunder-Link oligo conjugation system has been designed to allow the non-specialist to generate antibody oligonucelotide conjugates easily and efficiently.
MycoGuard Mycoplasma PCR Detection Kit from GeneCopoeia is a quick, simple and sensitive PCR-based mycoplasma detection kit.
GeneCopoeia offers several services for designing, creating and validating TALENs, TALE-TFs and other TAL effectors-based targeted genomic modification tools.
The UbiQuant ELISA from LifeSensors is intended for the accurate determination of total ubiquitin - including free ubiquitin, monoubiquitin and polyubiquitin - in biological samples.
The miProfile human miRNome miRNA qPCR arrays from GeneCopoeia are a set of nineteen 96-well plates covering 1565 of best characterised and annotated miRNAs based on miRBase V17.
The nitrofuran class of broad spectrum antibiotics (Nitrofurantoin, furazolidone, furaltadone and nitrofurazone) are commonly used in food-producing animals. The Abraxis Nitrofurantoin ELISA allows the determination of 41 samples in duplicate determination.
The Enzo Life Sciences BioArray Low Input RNA Amplification and Biotin Labeling System has improved the sensitivity of mRNA hybridising and labelling.
MédiMabs provides research-grade monoclonal and polyclonal antibodies, both novel and known, for which defined affinity and purity specifications exist.
The GeneCopoeia Lenti-Pac HIV and FIV qRT-PCR Lentivirus Titration Kits are designed for quick and simple titration of lentiviral particles to determine virus copy numbers and to confirm the success of packaging reactions.
The Polyclonal Anti-human C4d antibody from Biomedica has been designed to identify human complement split product C4d. It is suggested to be a valuable marker for humoral rejection of kidney transplantations.
Enzo Life Sciences offers more than 1500 catalogue small molecules, including regulators of key enzymes and cell signalling pathways. The company’s collection of over 30 focused compound libraries brings its complete offering of biologically active small molecules to over 3000.
Innova Biosciences has designed a range of accessory products which can be used to separate antibodies from unfavourable starting points. The kits are easy to use and are compatible with the Lightning-Link Antibody Labelling range.
ProteinTech produces antibodies from whole protein antigens for use as Western blot loading controls.
The Sclerostin ELISA from Biomedica is a highly sensitive ELISA for the measurement of human samples as small as 20 µL.
Abraxis has announced the availability of its Latex Agglutination Test (LAT) kits for the ‘big six’ non-O157 shiga toxin producing E. coli
(STEC). The kits are intended for identification of presumptive positive non-O157 STEC colonies.
Enzo Life Sciences offers a large selection of assays and reagents that facilitate personal care product development and toxicity testing.
Cosmo Bio has released antibodies for plant cells which can detect transporters localised in cell membranes and enzymes.
The Abraxis Glyphosate Kit applies the principles of enzyme linked immunosorbent assay (ELISA) to the determination of glyphosate in urine, soil, milk, lentils, white beans, soy beans, corn and malt barley.
Many foods contain Yellow Azo (Tartrazine) dyes in varying proportions. The Abraxis Yellow Azo dyes ELISA is an immunoassay for the quantitative and/or qualitative detection of Yellow Azo dyes (Tartrazine and related dyes).
United Bioresearch has available the complete range of Abraxis ELISA assays and test kits for real-time testing for endocrine disrupting chemicals, estrogens, antibiotics, pesticides, industrial chemicals, surfactants, marine biotoxins, cyanotoxins, mycotoxins, residues, additives and vitellogenin.
Cryopreservation is a practical and cost-effective method of archiving mouse strains in a laboratory.
GeneCopoeia has available hundreds of pre-made ORF cDNA lentiviruses along with their standard offering of special collection and custom-made lentiviruses.
Enzo Life Sciences CGH labelling kits generate high-quality DLR scores (0.09-0.12) which are said to exceed industry standards.
ProteinTech’s interactive ePathway site aims to give users access to the most up-to-date data on major signalling pathways such as p53, notch, hedgehog and Wnt.
HydraGene’s HyAgarose ‘green’ agarose is manufactured using technology that excludes the use of organic solvents. The agarose is said to have significantly reduced environmental impact while delivering the same reliable quality.
Rapid Assays has developed the generic rapid assay device (gRAD) with the aim of providing a simplified lateral flow assay system, to enable users to develop their own rapid point of sample assay, without the need for investing in production equipment.
The InnovaCoat Gold conjugation kit allows antibodies, proteins and other biomolecules to be covalently attached to ultrastable Gold nanoparticles with simple pipetting operations. The hands-on time for the conjugation procedure is about 2 min and the conjugate is ready to use within 15 min. The conjugation reaction is initiated by adding a solution of the antibody, which becomes attached (via lysine residues) to the InnovaCoat surface.
GeneCopoeia has introduced a budget-friendly collection of human ORF cDNA clones. The default format for these clones is bacterial stock, with additional charges for 10 and 50 ug purified plasmis.
Lightning-Link Rapid kits from Innova Biosciences allow antibody labelling reactions to be set up in seconds and used within less than 20 minutes. The range now incorporates the Thermo Fisher DyLight series of dyes.
GenomONE - CF EX
is a cell fusion kit that comprises Sendai virus envelope (SeV-E, HVJ Envelope, HVJ-E) and special buffers. It can be used with both adhering cells and suspension cells.
GenomONE-CAb Antibody Delivery Reagent is a tool for antibody introduction into cells in order to analyse intracellular function.
Enzo Life Sciences has expanded its collection of focused Screen-Well compound libraries with the release of the Wnt Pathway library.
Enzo Life Sciences’ wide selection of autophagy-related kits, small molecules, cell-based assays and reagents can be used to assess the process of autophagy from phagophore assembly through autolysosome creation and beyond. The range is claimed to provide rapid, quantitative results.
Enzo Life Sciences says it produces one of the most sensitive (0.037 pmol/mL) and complete colorimetric kits available for intra- and extracellular cAMP or cGMP quantification.
Enzo Life Sciences colorimetric ELISA kits for the quantitative determination of intracellular or extracellular cAMP or cGMP in cell lysates, culture supernatants, serum, saliva and tissue from any species are claimed to be the most sensitive and complete colorimetric ELISA kits.
The Innova Biosciences AbSelect Antibody Purification System readily removes unwanted substances such as proteins, preservatives and amino acids that can interfere with labelling reactions. It can either be used to purify antibodies from crude samples such as ascites fluid or serum, or from poor buffer formulations which may contain high concentrations of BSA, azide or Tris.
The miArrest miRNA inhibitors from GeneCopoeia can be used to achieve transient or stable knockdown in virtually all cell types.
Using a naturally secreted and robust Gaussia Luciferase (GLuc) as the reporter, GeneCopoeia GLuc-ON promoter clones are designed to detect the real-time activities of over 20,000 human promoters using live cell assays. GLuc is 1000-fold more sensitive than firefly or Renilla luciferase.
The Enzo Life Sciences CGH labelling kit for oligo arrays has been optimised to label DNA for dual sample comparative genomic hybridisation (CGH) assays on Agilent oligonucleotide arrays.
The Innova Biosciences Lightning Link antibody labelling kits are easy to use and require only 30 s hands-on time. The kits require no separation steps, which allows for 100% antibody recovery, and come in over 40 labels including the FluoProbes range.
The ProteoStat Thermal shift stability assay kit includes a fluorescent dye which detects protein aggregation, so it can be used to monitor protein stability under systematic thermal stress conditions. From the thermal shift assay, a temperature at which the bulk of the protein becomes aggregated can readily be identified.
GeneCopoeia offers genome-wide microRNA 3′ UTR target constructs in mammalian expression vector systems with luciferase reporter genes for functional validation experiments.
GeneCopoeia full-length expression-ready clones can be used to accelerate research and publish faster.
IDTox Assay Kits from ID Labs, available from United Bioresearch, are designed to monitor toxicity in mammalian serum samples.
The Fluor de Lys-Green HDAC assay is an HTS-compatible, homogenous assay for measuring histone deacetylase (HDAC) or sirtuin activity from cell or nuclear extracts, immunoprecipitates or purified enzymes.
Enzo Life Sciences’ FluoForte Calcium Assay kit provides a homogeneous fluorescence-based assay for detecting intracellular calcium mobilisation across a broad spectrum of biological targets. The dye yields a bright signal and a large assay window. The kit provides a homogeneous mix-and-read, no-wash calcium mobilisation assay.
Innova Biosciences has developed a conjugation technology called Lightning-Link that eliminates almost all of the steps employed in a traditional conjugation process.
DB Biotech has introduced a new technology for the production of highly specific RABBIT CLONAL antibodies. In vitro cloning technology developed by the company enables the preparation of a pure immunoglobulin fraction corresponding to a single clone of B lymphocytes.
Now available for the first time in Australia, the complete range of antibodies from Proteintech Group, Inc (PTG).
Enzo Life Sciences has incorporated both Alexis Biochemicals and Biomol International into its company. The entire range of Enzo’s comprehensive portfolio is now available in Australia and New Zealand through United Bioresearch Products.
The Drug Discovery range from Biomol International provides a combination of stock products and custom services to streamline drug discovery programs.
G protein-coupled receptors (GPCRs) are one of the major classes of drug targets and an estimated 30-50% of all marketed drugs act on them. They are integral membrane receptors that transmit signals from various small molecules, peptides and lipids via G proteins where they affect many physiological functions in almost all organs.
Biomol International supplies a comprehensive range of reagents that can be used in various aspects of neurodegenerative research. Areas of application include: Alzheimer’s (tau proteins and antibodies, BACE reagents, DSK3 and CDK5 reagents and neprilysin); Parkinson’s (synuclein antibodies and proteins, Parkin antibody, tyrosine hydroxylase antibodies and dopamine antagonists); Huntington’s (glutamate and NMDA reagents, HDAC inhibitors, HATs, IGF1 reagents and Akt reagents); and Multiple Sclerosis (myelin basic proteins, serotonin reuptake inhibitors, monoamine transport inhibitors and cannabinoids).
Corn Trypsin Inhibitor (CTI) from Haematologic Technologies is not only an inhibitor of trypsin but is also a specific human factor XIIa inhibitor when tested in blood-clotting experiments.
This GFP-certified apoptosis/necrosis detection system includes all the necessary reagents for determination of early and late stages of apoptosis as well as necrosis.
Haematologic Technologies is a primary manufacturer of high-quality coagulation proteins and research reagents.
Biomol International has introduced a monoclonal antibody that specifically recognises K63-linked polyubiquitin, but not any other isopeptide-linked (K6, K11, K27, K29, K33 or K48) polyubiquitinylated species.
BIOMOL International offers a comprehensive listing of products in the field of Endocannabinoid research. The company also manufactures other molecular tools which modulate levels of Endocannabinoids or block their uptake.
The Lightning-Link conjugation system from Innova Biosciences represents a quantum leap forward in conjugation technology. It allows the user to make antibody conjugates with minimal hands-on time — less than 30 seconds. It simplifies immunoassay techniques, such as western blotting, ELISA and immunohistochemistry, by eliminating secondary reagents and cutting the number of incubation and wash steps.
AMCELGROW Medium from ID Labs is optimised for the primary in vitro culture of human amniotic fluid cells and chorionic villi (CV) samples in open (5% CO2) systems. These primary cultures can then be used for such cytogenetic procedures as karyotyping and FISH.
To facilitate further development of new kinase inhibitors, BIOMOL offers over 120 active recombinant kinases and associated substrates for inhibitor screening or selectivity studies.
The SCAT series of collection tubes have been developed specifically to minimise in vitro artifact by rapidly quenching unwanted protease activity.
The Screen-Well collection of compound libraries from BIOMOL International are focused collections of compounds suitable for receptor de-orphaning, assay development and chemical genomics.
In order to investigate the status and extent of protein ubiquitinylation, it is necessary to have available a range of antibodies capable of differentiating firstly between free ubiquitin and ubiquitin-protein conjugates and, secondly, between those that are monoubiquitinylated and those that are polyubiquitinylated.
The Screen-Wellâ„¢ Protease Inhibitor Library from BIOMOL International includes 53 known protease inhibitors on a single 96-well plate.
HDACs are typically found in multiprotein complexes and are tightly regulated by subcellular localisation, phosphorylation, and likely by other mechanisms.