Malvern Panalytical Morphologi 4 with Morphologically Directed Raman Spectroscopy (MDRS)

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Identifying and characterising different structural forms of a compound can be crucial. This is especially true for acetaminophen, a common pain-relief medication that exists in multiple polymorphic forms. Process conditions, improper storage and simply time can cause the transition from a stable, efficacious form of a drug substance into an unwanted structural analogue.

Traditional characterisation techniques often struggle to both separate and identify the different species in a mixed system and lack the sensitivity to detect the low levels of polymorphic contaminants that may be present in final products. However, Malvern Panalytical’s Morphologi 4-ID system, which combines automated microscopy and Raman spectroscopy, offers a powerful solution.

This advanced approach, known as Morphologically Directed Raman Spectroscopy (MDRS), has been designed to enable the precise identification of individual particles and their composition within a mixture, to assist in determining the long-term stability of a product. By targeting particles with distinct morphologies for Raman analysis, MDRS can enhance measurement sensitivity, allowing for the detection of low-level polymorphic contaminants. Unlike traditional methods, the Morphologi 4 has the ability to combine morphological and chemical analysis in a single platform, providing insights into complex mixtures.

The Morphologi 4 is an effective method for characterising both particle shape and size from less than a micron to over a millimetre, replacing the time-consuming process of manual microscopy. Small differences in particle size and shape can impact both the flowability or cohesion properties and the final product performance, such as drug delivery, dissolution and bioavailability. Therefore, combining measurements should provide a more accurate picture of each individual particle, giving a deeper insight of a sample’s characteristics. This helps to resolve issues during the development of new formulations and products.

For more information: https://www.atascientific.com.au/products/malvern-morphologi-4/.