Molecular Devices MultiClamp 700B Microelectrode Amplifier

The MultiClamp 700B Microelectrode Amplifier from Molecular Devices is a computer-controlled microelectrode current- and voltage-clamp amplifier for electrophysiology and electrochemistry. The versatile amplifier is capable of single-channel and whole-cell voltage patch-clamp, high-speed current-clamp (sharp electrode or field potentials), ion-selective electrode recording, amperometry/voltammetry and bilayer recordings.

The amplifier is designed to support up to two primary CV-7B headstages and two optional auxiliary (HS-2 or VG-2 type) headstages. Each CV-7B headstage contains a current-to-voltage converter for voltage-clamp and a voltage follower for true current-clamp. This allows the user to conveniently switch between low-noise patch-clamp recording and high-speed current-clamp recording. An optional CV-7B/BL headstage is available for bilayer recording.

The small profile of the CV-7B headstage makes it easy to incorporate into an electrophysiology set-up. The dovetail design integrates with a base plate for easy attachment to micromanipulators. The headstage has four different feedback resistors in voltage-clamp mode, allowing for a wide range of cellular recording. In current-clamp mode, the headstage provides three different current setting resistors to clamp current from a few pA up to 200 nA.

The amplifier is fully controlled by the MultiClamp Commander software. Computer control allows for flexibility, including broad ranges of current passing and recording levels, extensive filtering options and multiple signal outputs.