Nicoya Lifesciences OpenSPR surface plasmon resonance instrument

Nicoya Lifesciences OpenSPR is a benchtop surface plasmon resonance (SPR) instrument designed to provide real-time molecular binding data without the use of labels on the molecules of interest. 

By measuring binding interactions as they occur, OpenSPR allows researchers to determine both the association rate constant (k_a) and dissociation rate constant (k_d) of a wide range of biomolecular interactions. A key benefit of SPR is that it does not require labelling molecules with fluorophores or metals, so molecular interactions may more closely resemble native behaviour.

OpenSPR is compatible with proteins, nucleic acids, small molecules and even viruses and cells. It has two flow channels which can be operated either independently or simultaneously to provide data on both an interaction of interest and a control. It has the capacity to measure ka from 1x10³ to 1x10⁷ 1/M*s and k_d from 0.1 to 1x10^-6, allowing determination of affinity constants ranging from mM to pM. The basic instrument is operated manually, but it can be upgraded with the XT autosampler to provide fully automated 24/7 operation.

With a compact footprint, the instrument easily fits on a benchtop and is targeted at research groups that frequently perform interaction studies and are seeking the convenience of having an instrument in their own lab.