Reduce the need for time-consuming and expensive analysis using Multi-Angle Dynamic Light Scattering (MADLS)

ATA Scientific Pty Ltd
Tuesday, 14 August, 2018

Reduce the need for time-consuming and expensive analysis using Multi-Angle Dynamic Light Scattering (MADLS)

Achieve higher resolution particle size and concentration analysis.

When producing particles of a known size, the amount of uniformity of the sample in terms of size and shape is essential to ensure consistency in biological experiments. In nanoparticle-based drug delivery studies for example, size and shape are important parameters that control the kinetics of internalisation, biodistribution, and cargo loading efficiency. While Transmission Electron Microscopy (TEM) is commonly used to characterise samples for QC, the technique can be time consuming, expensive and require an experienced user for the analysis. Multi-Angle Dynamic Light Scattering (MADLS) is a new technology from Malvern Panalytical that can reduce the amount of TEM analysis required and together with Adaptive Correlation can convey new insights into key sample properties including aggregate formation.

Why use light scattering?

Dynamic light scattering (DLS) is a non-invasive, well-established technique used to characterise molecules and particles typically in the submicron region, and with the latest technology lower than 1nm. The frequency and intensity of the scattered light can be measured to determine the size and charge of materials. This information is commonly used to shorten development time for, and improve the stability of, colloidal (including protein) and emulsion formulations, and to assess the levels of aggregation in a system.

The enduring appeal of the Malvern Zetasizer series

For over two decades, the Zetasizer range has been the de facto standard for performing DLS measurements on a wide range of particles and materials. Zetasizer systems are used across many industry sectors worldwide, delivering value in the control and optimisation of processes, and the improvement of product quality, stability and performance. They are central in academic settings, indispensable in a wealth of application spaces and referenced in tens of thousands of peer-reviewed publications.

The Zetasizer offers an easy-to use, highly flexible sizing method which is rapid, accurate and repeatable. It requires only small volumes of sample for analysis, and is non-destructive. Patented Non-Invasive Back-Scatter (NIBS) technology combines back-scatter detection with variable measurement positioning to significantly increase the range of sample concentration and size that can be measured, compared to conventional DLS.

Pushing the limits of DLS with the new Malvern Zetasizer Pro and Ultra

Built on the market-leading Zetasizer Nano range, the new Zetasizer Pro and Ultra systems from Malvern Panalytical are the latest iteration of the Zetasizer series. Several unique and powerful capabilities have been integrated in the new Zetasizer range, including:

  • Adaptive Correlation to characterise aggregated material
    By using statistical analysis and optimised data collection, Adaptive Correlation helps to improve the repeatability of DLS particle size measurements and the ability to measure primary particle sizes separately to rare amounts of aggregated material. These improvements mean that faster, higher precision measurements may be achieved with less need for filtering of samples and dispersants.
  • Multi-Angle Dynamic Light Scattering (MADLS®) for size and concentration analysis
    A key differentiator of the Zetasizer Ultra is its patented MADLS technology, which automates multiple-angle size measurements, providing higher resolution and more complete particle size distributions. MADLS also enables calibration-free particle concentration analysis, resolving the individual concentrations of different size populations. The new disposable capillary sizing cell provides non-destructive, low volume (3μL) analysis, extending the upper range to 10μm and delivering high-quality data while reducing cost.
  • Deep learning for simple method design and reliable, high quality data
    The Zetasizer Pro and Ultra systems are controlled by groundbreaking ZS Xplorer software, introducing new sample-centric workflows, which make method design and data analysis more straightforward for both new and experienced users. This intelligent network provides feedback on results and offers clear advice on how data may be improved if required.

If you would like further information or a free demonstration using the New Zetasizer Ultra, please contact us.

ATA Scientific Pty Ltd
+61 2 9541 3500

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