CN Bio PhysioMimix microphysiological system

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The PhysioMimix microphysiological system (MPS) is a suitable alternative to traditional in vitro experiments requiring animal models which are said to have inherent flaws and regulatory issues. PhysioMimix provides human-relevant data including comprehensive, 3D tissue culture-based data with real-time monitoring and analysis, allowing users to progress their research to clinical trials.

The lab benchtop device can be used to perform single- or multi-organ studies. Its open-well plate design enables the formation of three-dimensional micro-tissues that mimic the structure and function of human organs. Precise control of the fluidic environment can reveal how multiple organs interact and respond to drugs or other chemicals.

Cells and media can be sampled throughout experiments for analysis, including biomarker assays as well as imaging to visualise cell morphology, cell migration and protein marker localisation. Using this data, users can improve the efficiency of preclinical studies or industrial screening that require human-relevant data, according to the company.

Researchers in biopharma, academic and regulatory laboratories globally are using the platform to study primary cells, stem cells and organ mimetics in the liver, lung, gut, heart, kidneys, skin, endometrium and brain. PhysioMimix is also being used by the US Food and Drug Administration (FDA) to conduct organ-on-chip assays.

For more information: http://www2.axt.com.au/PMX.