Cosmo Bio Mebiol Gel 3D thermoreversible hydrogel

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Hydrogels are a diverse class of polymeric materials characterised by their network-like structure and high water content. They have found a wide variety of applications in medicine and life science research weighted towards, but not at all limited to, 3D cell culture, tissue engineering and drug delivery. Properties highly favourable to cell culture and tissue engineering applications prompted the commercialisation of Mebiol Gel, a copolymer of poly(N-isopropylacrylamide) and poly(ethylene glycol) (PNIPAAm-PEG).

A notable feature of Mebiol Gel is its temperature-reversible sol-gel transition. When cooled, the product handles like a liquid, but becomes a rigid hydrogel at higher temperatures. In practice, this means easy cell handling. Cultures are seeded into the cooled gel and recovered conveniently by cooling the culture vessel and centrifugation. In the gel state, the highly lipophylic environment of the product presents an efficient niche for cell proliferation, cell communication, gas and mass exchange, and protection of cells and tissue from shear forces.