Tongue microbes can help diagnose heart failure

Monday, 31 August, 2020

Tongue microbes can help diagnose heart failure

Microorganisms on the tongue could help diagnose heart failure, according to research recently presented at the online event HFA Discoveries — a scientific platform of the European Society of Cardiology.

As explained by study author Dr Tianhui Yuan, from the No.1 Affiliated Hospital of Guangzhou University of Chinese Medicine, “The tongues of patients with chronic heart failure look totally different to those of healthy people. Normal tongues are pale red with a pale white coating. Heart failure patients have a redder tongue with a yellow coating and the appearance changes as the disease becomes more advanced.

“Our study found that the composition, quantity and dominant bacteria of the tongue coating differ between heart failure patients and healthy people.”

Previous research has shown that microorganisms in the tongue coating could distinguish patients with pancreatic cancer from healthy people. The authors of that study proposed this as an early marker to diagnose pancreatic cancer. And, since certain bacteria are linked with immunity, they suggested that the microbial imbalance could stimulate inflammation and disease. Inflammation and the immune response also play a role in heart failure.

Dr Yuan’s study investigated the composition of the tongue microbiome in participants with and without chronic heart failure, enrolling 42 patients in hospital with chronic heart failure and 28 healthy controls. Stainless steel spoons were used to take samples of the tongue coating in the morning, before participants had brushed their teeth or eaten breakfast. A technique called 16S rRNA gene sequencing was used to identify bacteria in the samples.

The researchers found that heart failure patients shared the same types of microorganisms in their tongue coating. Healthy people also shared the same microbes. There was no overlap in bacterial content between the two groups.

At the genus level, five categories of bacteria distinguished heart failure patients from healthy people with an area under the curve (AUC) of 0.84 (where 1.0 is a 100% accurate prediction and 0.5 is a random finding). In addition, there was a downward trend in levels of Eubacterium and Solobacterium with increasingly advanced heart failure.

“More research is needed, but our results suggest that tongue microbes, which are easy to obtain, could assist with wide-scale screening, diagnosis and long-term monitoring of heart failure,” Dr Yuan said. “The underlying mechanisms connecting microorganisms in the tongue coating with heart function deserve further study.”

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