AdipoGen Life Sciences immunosuppressive antibiotics

AdipoGen Life Sciences is a provider of key standard antibiotics, rare metabolites/antibiotics and common immunosuppressive antibiotics for use in research. The company’s common immunosuppressive antibiotics are involved in cell proliferation pathways and include calcineurin (FK-506, cyclosporin A, ascomycin), mTOR (everolimus, rapamycin) and purine synthesis (mycophenolic acid) inhibitors.

Inhibition of calcineurin leads to inhibition of NFAT activation, reduced IL-2 production and consequently to reduced T cell proliferation. Inhibition of mTOR leads to inhibition of the IL-2 mediated cell cycle, which consequently blocks T cell activation, and B cell differentiation. Blockade of purine synthesis by inhibiting inosine monophosphate dehydrogenase (IMPDH) leads to a selective inhibition of lymphocyte proliferation.

Everolimus is a potent immunosuppressive antibiotic that binds with high affinity to the FK-506 binding protein-12 (FKBP12) to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin (mTOR). Furthermore, it shows anticancer and antibacterial activities. It is sourced from Streptomyces hygroscopicus (Actinobacteria).