AdipoGen Life Sciences InVivoKines recombinant fusion proteins

Cytokines are small proteins that facilitate communication among immune cells and orchestrate the response to infections and tumours as well as overall immune homeostasis, making them suitable for preclinical and clinical research for a variety of immune-related disorders. However, the widespread use of cytokines has been limited by their short blood half-lives, pleiotropism and unfavourable biodistribution.

InVivoKines are recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. The Fc-based fusion proteins were created using knobs-into-holes (KIH) technology; the Fc–KIH technology allows Fc heterodimerisation to create a structure with two different arms, to design naturally occurring active monomeric, heterodimeric or homodimeric proteins, and are also suitable for in vitro experiments.

Key features include: native conformation (production in HEK293 or CHO cells); production under animal-free conditions; high bioactivity tested by ELISA/cell-based assays; verified purity and homogeneity by SEC; low endotoxin levels; and batch-to-batch consistency.