AdipoGen Life Sciences SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit

Coronaviruses (CoVs) are enveloped non-segmented positive-sense RNA virus for human and vertebrates. They can infect the respiratory, gastrointestinal, hepatic and central nervous system of humans and many other wild animals. In December 2019, a new severe acute respiratory syndrome b-coronavirus called SARS-CoV-2 emerged, causing an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19).

The SARS-CoV-2 virus contains four structural proteins: spike (S), envelope (E), membrane (M) and nucleocapsid (N). The spike protein is a transmembrane protein, composed of the S1 subunit and S2 subunit. The S1 subunit contains a receptor-binding domain (RBD), which binds to the cell surface receptor angiotensin-converting enzyme 2 (ACE2) present at the surface of epithelial cells, causing infection of human respiratory cells. During an infection, IgM antibody appears first, followed by IgA on mucosal surfaces or IgG in the serum. The RBD and the nucleocapsid (N) are the main immunogens of coronavirus leading to an antibody response.

AdipoGen Life Sciences’ SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit is a sensitive and specific enzyme-linked immunosorbent assay (ELISA). The kit is intended to be used for the qualitative measurement of human immunoglobulin G (IgG) against SARS-CoV-2 spike (RBD) protein in serum and plasma. A false positive control plate is also included.