The RAFT 3D Culture System, from Lonza, allows researchers to overcome some of the challenges previously associated with working with 3D cultures. The cell culture system uses a high-density collagen scaffold to closely mimic the extracellular matrix of native tissues.
Cancer cells can be embedded in the collagen matrix, and many of them form tumour-like structures. The translucent properties of the system enable visualisation of these tumour-like structures with subcellular resolution under a fluorescence microscope.
The system permits different cancer cell types to show distinct morphologies, as well as characteristic tumour migration and invasion patterns. This can help researchers understand how to maximise the therapeutic potential of drugs in a more in vivo-like cell culture system.
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