The next evolution in 3D stem cell culture


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In vivo, cell behaviour is guided by a complex interplay with the extracellular matrix. Cells respond to mechanical, structural and biochemical cues from their extracellular matrix and these signals are necessary for achieving “normal” function. Based on the fact that cells respond just as strongly to signals they don’t receive as those that they do, StemBioSys® have invented the next generation of cell culture systems. Utilising their unique systems will result in more biologically and physiologically-relevant outcomes.

StemBioSys have developed CELLvo™ Matrix and CELLvo cells. CELLvo Matrix is the only substrate available that closely mimics the physical, structural and biochemical microenvironment found in the human body, providing a native three-dimensional microenvironment for cells. CELLvo cells are the only commercially-available cells isolated and expanded exclusively in their cell-derived matrix.

CELLvo Matrix and CELLvo Xeno-free Matrices

To create CELLvo Matrix the scientists at StemBioSys have induced human cells to secrete a matrix in cell culture dishes. That matrix is then decellularised, leaving behind a cell-derived extracellular matrix for cell culture. This biomimetic substrate provides the cues cells expect, enabling healthy phenotypes and biologically-relevant results from a variety of cell types.

When cells are taken from their niche, they respond with changes in their gene expression. On CELLvo Matrix, cells retain more natural gene expression, contributing to better phenotype retention during culture. This enables investigators to maintain healthier cells for more passages or pursue any number of applications where cell phenotype is important.

StemBioSys’s CELLvo Matrix is the only commercially available substrate that aims to recapitulate biochemical as well as structural and mechanical cues of the native niche by leaving the extracellular matrix intact. The thin layer of matrix at the bottom of the culture vessel is optically clear and cells grow in a monolayer on top, allowing for beautiful brightfield imaging. If your application requires fluorescence imaging, you can stain the cells directly on the CELLvo Matrix. StemBioSys also offers CELLvo Xeno-free Matrix, produced xeno-free allowing easy transition to translational studies.

CELLvo Cells

CELLvo cells are the only cells isolated and expanded using StemBioSys’ CELLvo Matrix technology. By isolating cells on a cell-derived extracellular matrix, it is possible to preserve more natural phenotypes. All StemBioSys cells are early-passage, xeno-free whenever possible and from young, healthy tissue to ensure customers have top quality cells.

CELLvo Matrix technology enables the efficient isolation of rare populations of cells that are difficult to isolate with other culture tools. Thanks to this cutting-edge technology, StemBioSys currently offers the following types of CELLvo Cells:

  • Human Chondrocytes
  • Human Bone Marrow Mesenchymal Stem Cells
  • Human Wharton’s Jelly Mesenchymal Stem Cells
  • Human Adipose Mesenchymal Stem Cells
  • Human Endothelial Progenitor Cells

Your work is important

CELLvo cells are the only commercially-available stem cells isolated and expanded on a cell-derived extracellular matrix. Furthermore, the CELLvo Matrix provides a native three-dimensional microenvironment composed of more than 150 proteins to culture your cells. Together, the cells and matrix eliminate cell culture artifacts and allow the cells to respond to your experimental variables instead of foreign culture conditions. Consequently, you will get more transferable and biologically-relevant data from your in vitro work.

Top image credit: ©stock.adobe.com/au/nikilitov

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