Older paternal age linked to neurodevelopmental disorders

Wednesday, 22 April, 2020

Older paternal age linked to neurodevelopmental disorders

A recent epidemiological survey of approximately 6 million people worldwide has revealed that advanced paternal age is associated with the development of neurodevelopmental disorders in children. In other words — the older the father, the increased risk a child has of developing disorders such as autism, ADHD and other learning disabilities.

Now, a research team from the Department of Developmental Neuroscience at Tohoku University has revealed further details about this phenomenon. Led by doctoral student Misako Tatehana and Professor Noriko Osumi, the team performed immunohistochemical analysis of the testis in three-month-old mice before performing the same analysis on mice aged 12 months or older.

Tatehana and her team analysed histone proteins during the 12-step spermatogenesis process. Histone proteins undergo chemical modifications during spermatogenesis, thereby affecting gene expression. More specifically, the team looked at the seven methylations and one acetylation. They catalogued these as epigenetic markers — modifications that affect the expression of the gene without changing the DNA base sequence of the genome itself.

Comparisons of the markers between the younger and older mice using imaging quantification techniques revealed that the latter had higher amounts of the modified histone protein H3K79me3. A previous study by Prof Osumi found a correlation between the amount of H3K79me3 in sperm and abnormal speech communication in pups, making it a predictive marker of neural-developmental disorders.

The team’s findings, published in the journal PLOS ONE, indicate that paternal ageing potentially affects neurodevelopment in humans. Further research on the matter hopes to develop greater diagnostic methods for disorders stemming from the risk of advanced paternal age.

Image credit: ©iStockphoto.com/GlobalStock

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