Small molecular screening libraries for developmental biology

UK-based company AMS Biotechnology (AMSBIO) has announced the launch of its PATHM² small molecule libraries for small-scale screening in developmental biology and discovery research.

The PATHM² libraries are available to identify accessory molecules that improve cell viability, proliferation or yields. All compounds are selected to address ‘traditional’ cascades that play a role in pluripotency maintenance or specific differentiation. Multiple agents are included to interrogate new and emerging networks/targets relevant to stem cell biology.

PATHM² kits are also available to screen the user’s disease model and identify and/or confirm critical pathways and targets. Using the kits, users will be able to find disease state modulators as starting points for further refinement.

All small molecule compounds in the kits have drug-/lead-like properties, good water solubility, bio-membrane permeability, an activity/selectivity profile and potential for optimisation. AMSBIO also provides one-stop, scale-up medicinal chemistry, screening and development services.

In addition, PATHM² kits can be used to study selected signalling pathways of interest. Custom sets are available to identify more selective and potent small molecules to replace inferior but still commonly used ones.

For further information on the libraries and kits, visit http://www.amsbio.com/stem_cell_small_molecules.aspx.