Tolerance for Novogen
Friday, 27 February, 2009
Interim results from a Phase II clinical trial in prostate cancer patients by Novogen’s subsidiary Marshall Edwards have shown the oral dose is well tolerated with no serious adverse events.
The US trial is studying the anti-tumour effects of phenoxodiol, an inhibitor of the pro-survival regulator sphingosine-1-phosphate (S-1-P).
Marshall Edwards is developing the product as a combination therapy for chemo-resistant ovarian cancer and as a monotherapy for cervical cancer.
The compound is also being studied as a monotherapy in prostate cancer, and in combination with the chemotherapy drugs cisplatin or carboplatin.
A study conducted by St George Hospital’s Professor Paul de Souza found phenoxodiol was able to enhance the activity of cisplatin and carboplatin in prostate cancer cells in vitro.
For the full story, see the March/April issue of Australian Life Scientist.
Babies of stressed mothers likely to get their teeth earlier
Maternal stress during pregnancy can speed up the timing of teeth eruption, which may be an early...
Customised immune cells used to fight brain cancer
Researchers have developed CAR-T cells — ie, genetically modified immune cells manufactured...
Elevated blood protein levels predict mortality
Proteins that play key roles in the development of diseases such as cancer and inflammation may...
