New findings in drug-induced receptor activity using the Roche xCELLigence system
A research team, led by Dr Michel Bouvier at the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal in Quebec, has used the Roche xCELLigence SP Instrument to measure changes in cell response following ligand.
According to the findings, selective pharmacological inhibition of specific arms of the β2AR signalling network was able to correlate the differential contribution of signalling events to specific components of the cell response. The essential role of intracellular Ca2+ in the cell response also led to the discovery of a novel β2AR-promoted Ca2+ mobilisation event.
The discovery that drugs targeting a single G protein-coupled receptor (GPCR) can differentially modulate distinct subsets of the receptor signalling repertoire is a very important step in drug discovery. Findings of the present study underscore the power of using real-time cell monitoring to dissect the pluridimensionality of GPCR signalling using integrative approaches for a comprehensive readout of drug-induced cellular activity.
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