Merck has launched its CRISPR inhibition (CRISPRi) whole-genome libraries and pools to complement its suite of genome-editing products and technologies.
The platform helps to overcome lentiviral production challenges and can reduce process development time by approximately 40%, according to the company.
Merck has unveiled the Bio4C Software Suite, creating a digital ecosystem that combines process control, analytics and plant-level automation.
Merck has developed a filtration-based manufacturing process resulting in a highly purified sucrose grade with reduced levels of nanoparticle impurities (NPI). The product — Sucrose EMPROVE EXPERT Ph Eur, ChP, JP, NF — is suitable for the high-risk applications of manufacturing and formulating biomolecules.
Merck has launched its Parteck COAT excipient — a functional material designed for immediate release film coating applications.
Merck has introduced its ADC Express services for the rapid production of ADCs, designed to reduce the time needed to produce development-grade constructs for target molecule identification.
Merck has launched its Plug & Play Upstream Development Service to help emerging biotech and start-up companies advance their molecules to the clinical stage.
Merck's Pellicon Capsule with Ultracel Membrane is a single-use tangential flow filtration capsule for bioprocessing of antibody-drug conjugates and monoclonal antibodies. The capsule is designed to reduce the risk of product cross-contamination, as well as exposure to toxic compounds during both processing and disassembly.
Merck has launched the Eshmuno P anti-A and Eshmuno P anti-B affinity chromatography resins, specifically designed to remove anti-A and anti-B isoagglutinin antibodies during the manufacturing of plasma-derived immunoglobulin (Ig) therapies.
Merck's portfolio of 3 to 2000 L Mobius single-use bioreactors delivers flexibility and continuity for scale-up, reducing the need for retraining operators.
Merck's Advanced Proteomics Grade SOLu-Trypsin is a solution-stable enzyme for mass spectrometry. Designed to be stable in solution when refrigerated, the enzyme can be used immediately without preparation.
Merck's EZ-Fit Filtration Units for microbial enumeration are stackable to save on laboratory space.
MilliporeSigma has expanded its line of Guava easyCyte flow cytometers to include a high-power modulated green laser. The system combines the green laser, higher power violet, blue and red lasers for detecting subcellular particles as small as viruses, low waste volume and a small footprint.
The Merck CellASIC ONIX 2 Microfluidic Platform enables simplified, dynamic and precise live cell analysis. The platform allows researchers to monitor responses to perfusion, temperature and gas environment changes in live cells and track individual cell responses over time for truly dynamic cellular analysis.
Merck is launching three Mobius products that deliver improved efficiency and ease of use for biopharmaceutical manufacturing workflows. The products include a 1000 L single-use bioreactor, a 2000 L mixing system for difficult-to-mix biopharm ingredients and a large-volume liquid transport system for aseptic and non-aseptic substances.
The AldeRed ALDH Detection Assay, from Merck Millipore, provides cancer and stem cell scientists with more capabilities for live cell isolation and characterisation.
The PureGenome Low Input NGS Library Construction Kit streamlines the process of generating indexed or barcoded libraries for Illumina HiSeq sequencing from low amounts of input DNA (from 50 pg to 1 ng).
The CellASIC ONIX Microfluidic Platform, in conjunction with the CellASIC ONIX Microfluidic Plates, provides perfusion-based microenvironment control for long-term, live cell microscopy.
Merck Millipore offers the guava easyCyte 12 flow cytometer, a simple and powerful benchtop method for multicolour flow cytometry. The system has been shown to detect particles as small as 0.2 μm, which is said to be a significant improvement over typical flow cytometers.
Merck Millipore has announced its AFS 40E, 80E, 120E and 150E water purification systems, developed to provide clinical laboratories with an economical water purification solution for daily water volumes of up to 3000 L.
The Amnis NFкB Translocation kit allows researchers to study the nuclear translocation of NFкB - a transcription factor that plays a central role in regulating key mammalian cell processes, including proliferation, inflammation, immune and stress responses.
Merck Millipore has introduced the SNAP i.d. 2.0 protein detection system for immunohistochemistry (IHC), which is said to streamline immunohistochemistry workflows and decrease slide handling time.
Guava easyCyte flow cytometers are amenable to on-demand use in the laboratory environment and help scientists achieve insightful cellular analysis. The flow cytometry systems are easy to use and deliver complete and comprehensive cell analysis right on the benchtop.
Merck Millipore has introduced the Magna Nuclear RNA-binding Protein Immunoprecipitation (RIP) kits. The kits are designed to allow the discovery and analysis of both coding and non-coding chromatin-associated RNAs.
Merck Millipore has offered chromatography products since 1904, with columns, plates and mobile phases used in mass spectrometry (MS) labs throughout the world. Solutions for Mass Spectrometry is a compendium packed with information on this analytical field.
Merck Millipore has introduced a recombinant protein purification protocol that combines lysis and purification into a single step. The condensed workflow can be completed in about 45 min, which is said to reduce processing time by 75% compared to traditional techniques while delivering high yield and purity.
With Merck Millipore's Direct Detect spectrometer, the user is simply required to spot 2 μL of the sample, blank with buffer and read. There is no sample prep, no tedious standard curves and no messy cuvettes or liquid waste.
The Msynth plus line, from Merck Millipore, makes qualification of starting materials simple. Developed for organic synthesis in quality-conscious or regulated environments, such as the pharma, electronics or cosmetics industries, Msynth plus products are accompanied by the necessary quality documentation to help users easily fulfil regulatory requirements.
The SmartFlare detection reagent is a novel probe capable of detecting specific mRNAs and miRNAs in live, intact cells. The technology allows for carrier-free cellular endocytosis of the reagent, followed by detection and relative quantitative analysis of RNA levels.
Merck Millipore has added three products to its EZ-product family, which is designed to facilitate microbiology workflow in quality assurance and quality control (QA/QC) laboratories.
The Duran Group Laboratory Glassware catalogue Edition 4 is now available online.
Merck has introduced N,N-Dimethylformamide and Dimethyl sulfoxide, two SupraSolv solvents designed to meet the requirements of headspace gas chromatography: high purity and low concentrations of residual solvents.
Merck Millipore has added the Elix Essential systems to its range of Elix water purification equipment. The systems integrate Elix electrodeionisation (EDI) technology along with several other complementary water purification techniques (eg, pretreatment, reverse osmosis and UV lamp treatment) in order to produce Type 2 pure water with consistently pure and reliable water quality.
Merck Millipore has launched the Direct Detect system for rapid, simplified protein quantitation. The system enables infrared-based measurement of amide bonds in protein chains, an intrinsic component of every protein, without relying on amino acid composition, dye-binding properties or redox potential.
Merck Millipore has launched two ProteoExtract Kits that enable researchers to more rapidly and effectively enrich, isolate and analyse the cytoskeleton and associated proteins.
EMD Millipore, the life science division of Merck KGaA, has launched QCM Gelatin Invadopodia Assays which are designed to standardise and enhance the study of cell invasion. The assays are claimed to be the only commercially available kits for studying invadopodia.
Merck Millipore has released a simple to use Analytical Application Finder that allows users to search for HPLC applications to suit their sample. The Analytical Application Finder has hundreds of applications for the pharmaceutical, food and beverage, bioscience or research and development fields.
The Merck Millipore Magna ChIP-Seq preparation kit has been designed to simplify genome-wide profiling of DNA-protein interactions by chromatin immunoprecipitation and next-generation sequencing (ChIP-Seq).
Merck has released a new positioning concept for its solvents, acids, caustics and salts so users will now be able to quickly and efficiently find the right product for their application.
The continuous background conductivity suppression system SeQuant CARS Continuous Anion Regeneration System equipped with the SeQuant SAMS Membrane Suppressor for Anion Chromatography can be used to simplify the determination of anions by ion chromatography.
Novagen has introduced multiplex immunoassays for the bead-based Luminex xMAP Technology platform. The range of immuno-assays allows the multiplex quantification of phosphorylated proteins, giving researchers the opportunity to examine changes in cellular signalling that reflect disease states or various drug treatments.
Merck can offer a wide range of deuterated solvents with low residual water, high chemical purity and high isotopic enrichment.
Reproducible HPLC separations require solvents to have a high degree of UV transmittance, low particle count, low acidity and alkalinity and a low level of evaporation residue. Merck’s LiChrosolv solvents meet these requirements; they are produced from specially selected raw materials and undergo a number of purification steps before final packaging.
The Seccosolv solvents are ready-to-use products of high purity and with minimal water content. They are produced with distillation methods that result in consistently high dryness and batch-to-batch consistency.
Apura, the latest generation of reagents from Merck, can be used for all Karl Fischer applications.
The IQ120, IQ125 and IQ128 MiniLab waterproof non-glass pocket pH meters are compact devices featuring advanced silicon chip (ISFET) pH sensors that provide stable readings in seconds.
The Merck chemicals catalogue has been released. Like its predecessor, it contains information about reagents, analytical test kits, pigments, products for chromatography, microbiology and microscopy.
Merck has a range of sample preparation instruments for the digestion of water and wastewater samples prior to photometric analysis. It is often necessary to digest a sample to determine the concentration of a specific analyte that is in a complex, bound or colloidal form. This can be done with the addition of a digestion reagent and heating in a block heater (thermoreactor).
Spectroquant Nova 30/60 Photometers have a diode array design with no moving parts. Barcoded sample vials eliminate the need to select methods and wavelengths manually.